Human Gene Set: GSE15215_CD2_POS_VS_NEG_PDC_DN


Standard name GSE15215_CD2_POS_VS_NEG_PDC_DN
Systematic name M3521
Brief description Genes down-regulated in comparison of CD2+ plasmacytoid dendritic cells (DC) versus CD2- cells.
Full description or abstract Plasmacytoid dendritic cells (pDCs) are key regulators of anti-viral immunity. They rapidly secrete IFN-alpha and cross-present viral antigens thereby launching adaptive immunity. Here we show that activated human pDCs inhibit replication of cancer cells, and kill them in a contact dependent fashion. Expression of CD2 distinguishes two pDC subsets with distinct phenotype and function. Both subsets secrete IFN-alpha and express Granzyme B and TRAIL. CD2high pDCs uniquely express lysozyme and can be found in tonsils and in tumors. Both subsets launch recall T cell response. However, CD2high pDCs secrete higher levels of IL12 p40, express higher levels of co-stimulatory molecule CD80 and are more efficient in triggering proliferation of na´ve allogeneic T cells. Thus, human blood pDCs are composed of subsets with specific phenotype and functions.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 19454677   Authors: Matsui T,Connolly JE,Michnevitz M,Chaussabel D,Yu CI,Glaser C,Tindle S,Pypaert M,Freitas H,Piqueras B,Banchereau J,Palucka AK
Exact source GSE15215_1537_200_DN
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Organism Homo sapiens
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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