Systematic name M3660
Brief description Genes up-regulated in comparison of stimulated memory CD8 T cells from pmel-1 mice versus stimulated naive CD8 T cells from pmel-1 mice.
Full description or abstract Effector cells for adoptive immunotherapy can be generated by in vitro stimulation of na´ve or memory subsets of CD8+ T cells. While the characteristics of CD8+ T cell subsets are well defined, the heritable influence of those populations on their effector cell progeny is not well understood. We studied effector cells generated from na´ve or central memory CD8+ T cells and found that they retained distinct gene expression signatures and developmental programs. Effector cells derived from central memory cells tended to retain their CD62L+ phenotype, but also to acquire KLRG1, an indicator of cellular senescence. In contrast, the effector cell progeny of na´ve cells displayed reduced terminal differentiation, and, following infusion, they displayed greater expansion, cytokine production, and tumor destruction. These data indicate that effector cells retain a gene expression imprint conferred by their na´ve or central memory progenitors, and they suggest a strategy for enhancing cancer immunotherapy.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 19805141   Authors: Hinrichs CS,Borman ZA,Cassard L,Gattinoni L,Spolski R,Yu Z,Sanchez-Perez L,Muranski P,Kern SJ,Logun C,Palmer DC,Ji Y,Reger RN,Leonard WJ,Danner RL,Rosenberg SA,Restifo NP
Exact source GSE16522_1392_200_UP
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Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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