Human Gene Set: GSE18804_BRAIN_VS_COLON_TUMORAL_MACROPHAGE_UP
Standard name
GSE18804_BRAIN_VS_COLON_TUMORAL_MACROPHAGE_UP
Systematic name
M10021
Brief description
Genes up-regulated in tumor associated macrophages conditioned by: glioblastoma versus colorectal adenocarcinoma.
Full description or abstract
Active immunotherapy is a promising strategy for anti-angiogenic cancer therapy. Recently, we have reported that a vaccine using human umbilical vein endothelial cells (HUVECs) induced specific anti-endothelial immune responses in the most of immunized patients, and resulted in tumor regression in some patients with recurrent malignant brain tumors, whereas not in colorectal cancer patients. In this study, we hypothesized that non-hypoxic perivascular tumor associated macrophages (TAMs) in colorectal cancer, but not in glioblastoma, might negatively alter the therapeutic efficacy of anti-angiogenic active immunotherapy. To test this hypothesis, we examined global gene expression profiles of non-hypoxic macrophages stimulated in vitro by soluble factors released from tumor cells of human glioblastoma U-87MG (?brain TAMs?) or colorectal adenocarcinoma HT-29 (?colon TAMs?).
