Human Gene Set: GSE21678_WT_VS_FOXO1_FOXO3_KO_TREG_DN


Standard name GSE21678_WT_VS_FOXO1_FOXO3_KO_TREG_DN
Systematic name M7394
Brief description Genes down-regulated in T reg cells: wildtype versus FOXO1 and FOXO3 [GeneID=2308;2309].
Full description or abstract Identification of Foxos target genes in Treg cells. Foxo1and Foxo3 are transcription factors of Foxo family. CD4+Foxp3+ Treg cells isolated from wild-type and Foxo1/3-deficient mice were analyzed by global gene expression profiling. Results indicate Foxos regulate expression of a subset of Treg cell signature genes and genes in control of T cell homeostasis, signaling and metabolism.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 20467422   Authors: Ouyang W,Beckett O,Ma Q,Paik JH,DePinho RA,Li MO
Exact source GSE21678_2640_200_DN
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Organism Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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