Systematic name M8435
Brief description Genes up-regulated in CD8 T cells: central memory versus na´ve.
Full description or abstract An early-differentiated CD8+ memory T cell subset with stem cell-like properties (TSCM) can be identified within the na´ve-like T cell population by the expression of CD95/Fas. Based on experiments including exon- and gene-level expression analysis, we provide evidence that this subset of antigen-specific cells represents an early precursor of conventional central (TCM) and effector (TEM) memory CD8+ T cells with enhanced self-renewal capacity and proliferative potential. We identified 900 genes differentially expressed between major T cell subsets defined along with memory T cell commitment. Based on the analysis of these genes, CD95+ na´ve T cells (TSCM) cluster closer to the CD8+ T memory compartment than to classical (CD95-) na´ve T (TN) cells, and display an intermittent phenotype between classical TN and TCM cells in terms of all major T cell differentiation markers analyzed.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 21926977   Authors: Gattinoni L,Lugli E,Ji Y,Pos Z,Paulos CM,Quigley MF,Almeida JR,Gostick E,Yu Z,Carpenito C,Wang E,Douek DC,Price DA,June CH,Marincola FM,Roederer M,Restifo NP
Exact source GSE23321_2649_200_UP
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Source species Homo sapiens
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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