Systematic name M8507
Brief description Genes down-regulated in CD8 T cells: control versus over-expressing ID3 [GeneID=3399].
Full description or abstract Mouse CD8+ T cells affected by ID3 (Inhibitor of DNA binding 3) display patterns of gene expression suggesting enhanced persistance and survival. In this study, we identified genes differentially expressed between ID32a transduced and mock transduced, and ID32a knockout and wild type mouse CD8+ T cells. Most prominent functions of differentially expressed genes include DNA replication-associated repair, maintenance of chromosome stability and mitotic cell divison machinery. Overall, these data suggest that ID3 acts in favor of maintained survival in CD8+ mouse T cells.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 22057288   Authors: Ji Y,Pos Z,Rao M,Klebanoff CA,Yu Z,Sukumar M,Reger RN,Palmer DC,Borman ZA,Muranski P,Wang E,Schrump DS,Marincola FM,Restifo NP,Gattinoni L
Exact source GSE23568_2918_200_DN
Related gene sets (show 7 additional gene sets from the source publication)

(show 73 gene sets from the same authors)
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Organism Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
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Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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