Human Gene Set: GSE23568_ID3_TRANSDUCED_VS_ID3_KO_CD8_TCELL_DN


Standard name GSE23568_ID3_TRANSDUCED_VS_ID3_KO_CD8_TCELL_DN
Systematic name M8506
Brief description Genes down-regulated in CD8 T cells: over-expressing ID3 [GeneID=3399] versus ID3 [GeneID=3399] knockout.
Full description or abstract Mouse CD8+ T cells affected by ID3 (Inhibitor of DNA binding 3) display patterns of gene expression suggesting enhanced persistance and survival. In this study, we identified genes differentially expressed between ID32a transduced and mock transduced, and ID32a knockout and wild type mouse CD8+ T cells. Most prominent functions of differentially expressed genes include DNA replication-associated repair, maintenance of chromosome stability and mitotic cell divison machinery. Overall, these data suggest that ID3 acts in favor of maintained survival in CD8+ mouse T cells.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 22057288   Authors: Ji Y,Pos Z,Rao M,Klebanoff CA,Yu Z,Sukumar M,Reger RN,Palmer DC,Borman ZA,Muranski P,Wang E,Schrump DS,Marincola FM,Restifo NP,Gattinoni L
Exact source GSE23568_2920_200_DN
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Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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