Systematic name M7842
Brief description Genes down-regulated in T conv cells: control versus treated with IL35.
Full description or abstract Regulatory T cells (Tregs) play a critical role in the maintenance of immunological self-tolerance. Na´ve human or murine T cell treatment with the inhibitory cytokine IL35 induces a regulatory population, termed iTR35, that mediates suppression via IL35, but not IL10 or TGF?, neither express nor require Foxp3, are strongly suppressive in five in vivo models, and exhibit in vivo stability. Treg-mediated suppression induces iTR35 generation in an IL35- and IL10-dependent manner in vitro, and in inflammatory conditions in vivo in Trichuris-infected intestines and within the tumor microenvironment, where they appear to contribute to the regulatory milieu. iTR35 may constitute a key mediator of infectious tolerance and may contribute to Treg-mediated tumor progression, and ex vivo-generated iTR35 may possess therapeutic utility.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 20953201   Authors: Collison LW,Chaturvedi V,Henderson AL,Giacomin PR,Guy C,Bankoti J,Finkelstein D,Forbes K,Workman CJ,Brown SA,Rehg JE,Jones ML,Ni HT,Artis D,Turk MJ,Vignali DA
Exact source GSE24210_2705_200_DN
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Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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