Human Gene Set: GSE24210_IL35_TREATED_VS_RESTING_TREG_DN


Standard name GSE24210_IL35_TREATED_VS_RESTING_TREG_DN
Systematic name M7843
Brief description Genes down-regulated in T conv cells treated with IL35 versus resting T reg cells.
Full description or abstract Regulatory T cells (Tregs) play a critical role in the maintenance of immunological self-tolerance. Naïve human or murine T cell treatment with the inhibitory cytokine IL35 induces a regulatory population, termed iTR35, that mediates suppression via IL35, but not IL10 or TGF?, neither express nor require Foxp3, are strongly suppressive in five in vivo models, and exhibit in vivo stability. Treg-mediated suppression induces iTR35 generation in an IL35- and IL10-dependent manner in vitro, and in inflammatory conditions in vivo in Trichuris-infected intestines and within the tumor microenvironment, where they appear to contribute to the regulatory milieu. iTR35 may constitute a key mediator of infectious tolerance and may contribute to Treg-mediated tumor progression, and ex vivo-generated iTR35 may possess therapeutic utility.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 20953201   Authors: Collison LW,Chaturvedi V,Henderson AL,Giacomin PR,Guy C,Bankoti J,Finkelstein D,Forbes K,Workman CJ,Brown SA,Rehg JE,Jones ML,Ni HT,Artis D,Turk MJ,Vignali DA
Exact source GSE24210_2710_200_DN
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Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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