Systematic name M8357
Brief description Genes up-regulated in atherosclerosis macrophages: anti miR-33 versus anti miR.
Full description or abstract Inhibition of miR-33 results in increased cholesterol efflux and HDL-cholesterol levels in mice. In this study we examined the effect of miR-33 inhibition in a mouse model of atherosclerosis and observed significant reduction in atherosclerotic plaque size. At the end of the study, gene expression in macrophages from the atherosclerotic plaques was assessed. The results demonstrated a reduction in inflammatory gene expression and increased levels of mRNAs containing miR-33 binding sites.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 21646721   Authors: Rayner KJ,Sheedy FJ,Esau CC,Hussain FN,Temel RE,Parathath S,van Gils JM,Rayner AJ,Chang AN,Suarez Y,Fernandez-Hernando C,Fisher EA,Moore KJ
Exact source GSE28783_3377_200_UP
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Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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