Human Gene Set: GSE32423_CTRL_VS_IL7_MEMORY_CD8_TCELL_DN
Standard name
GSE32423_CTRL_VS_IL7_MEMORY_CD8_TCELL_DN
Systematic name
M5084
Brief description
Genes down-regulated in comparison of memory CD8 T cells versus those treated with IL7 [GeneID=3574].
Full description or abstract
Effects of IL-4 on CD8 T cells functions are largely unknown. IL-4 induces survival and proliferation of CD8 T cells, but several studies suggest that IL-4 could also affect several functions of CD8 T cells such as cytotoxicity. Our team has shown that IL-4 repress the expression of Ccl5 in vitro. To define more precisely the impact of IL-4 on CD8 T cells, we performed a whole genome expression microarray analysis of naive and memory CD8 T cells cultured in presence or absence of IL-4. This approach allowed us to define the IL4-gene-expression signature on CD8 T cells.