Human Gene Set: GSE32901_TH1_VS_TH17_NEG_CD4_TCELL_DN


Standard name GSE32901_TH1_VS_TH17_NEG_CD4_TCELL_DN
Systematic name M8923
Brief description Genes down-regulated in CD4 [GeneID=920] T cells: Th1 versus Th17 negative.
Full description or abstract In this study, we examined differential gene expression in na´ve human CD4+ T cells, as well as in effector Th1, Th17-negative and Th17-enriched CD4- T cell subsets. We observed a marked enrichment for increased gene expression in effector CD4+ T cells compared to naive CD4+ among immune-mediated disease oci genes. Within effector T cells, expression of disease-associated genes was increased in Th17-enriched compared to Th17-negative cells. We used microarray to examine the gene expresssion profile and level of human na´ve, Th1 and effector T cell subsets.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 22715389   Authors: Zhang W,Ferguson J,Ng SM,Hui K,Goh G,Lin A,Esplugues E,Flavell RA,Abraham C,Zhao H,Cho JH
Exact source GSE32901_3356_200_DN
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Source species Homo sapiens
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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