Systematic name M9427
Brief description Genes down-regulated in wildtype DN3 thymocytes versus T cell lymphoma cells from TCF7 [GeneID=6932] knockout.
Full description or abstract TCF-1 is an HMG family transcription factor which is known to be critical for T cell development. We discovered that it has a unique role in suppressing malignant transformation of developing thymocytes at early stages. We identified ID2 and LEF-1 as key TCF-1 target genens in tumor suppression. We used microarrays to detect gene expression changes in WT and TCF-1 deficient DN3 thymocytes as well as T cell lymphoma cells developed in TCF-1 KO mice.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 23103132   Authors: Yu S,Zhou X,Steinke FC,Liu C,Chen SC,Zagorodna O,Jing X,Yokota Y,Meyerholz DK,Mullighan CG,Knudson CM,Zhao DM,Xue HH
Exact source GSE33292_2590_200_DN
Related gene sets (show 5 additional gene sets from the source publication)

(show 109 gene sets from the same authors)
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Organism Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
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NCI-60 cell lines (National Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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