Human Gene Set: GSE36826_NORMAL_VS_STAPH_AUREUS_INF_IL1R_KO_SKIN_UP


Standard name GSE36826_NORMAL_VS_STAPH_AUREUS_INF_IL1R_KO_SKIN_UP
Systematic name M9531
Brief description Genes up-regulated in skin with IL1R1 [GeneID=3554] knockout: uninfected versus S. aureus infection.
Full description or abstract Neutrophil abscess formation is critical in innate immunity against many pathogens. Here, the mechanism of neutrophil abscess formation was investigated using a mouse model of Staphylococcus aureus cutaneous infection. Gene expression analysis of S. aureus-infected skin revealed that induction of neutrophil recruitment genes was largely dependent upon IL-1beta/IL-1R activation. Unexpectedly, using IL 1beta reporter mice, neutrophils were identified as the primary source of IL-1beta at the site of infection. Furthermore, IL-1beta-producing neutrophils were necessary and sufficient for abscess formation and bacterial clearance. S. aureus-induced IL 1beta production by neutrophils required TLR2, NOD2, FPRs and the ASC/NLRP3 inflammasome. Taken together, IL-1beta and neutrophil abscess formation during an infection are functionally, spatially and temporally linked as a consequence of direct IL-1beta production by neutrophils.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 23209417   Authors: Cho JS,Guo Y,Ramos RI,Hebroni F,Plaisier SB,Xuan C,Granick JL,Matsushima H,Takashima A,Iwakura Y,Cheung AL,Cheng G,Lee DJ,Simon SI,Miller LS
Exact source GSE36826_2304_200_UP
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Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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