Systematic name M9309
Brief description Genes down-regulated in CD4: na´ve versus FOXP3 [GeneID=50943] knockout T reg precursors.
Full description or abstract Regulatory T (Treg) cells, whose identity and function are defined by the transcription factor Foxp3, are indispensable for immune homeostasis. It is unclear whether Foxp3 exerts its Treg lineage specification function through active modification of the chromatin landscape and establishment of new enhancers or by exploiting a pre-existing enhancer landscape. Analysis of the chromatin accessibility of Foxp3-bound enhancers in Treg and Foxp3-negative T cells showed that Foxp3 was bound overwhelmingly to pre-accessible enhancers occupied by its cofactors in precursor cells or a structurally related predecessor. Furthermore, the bulk of Foxp3-bound Treg cell enhancers inaccessible in Foxp3- CD4+ cells became accessible upon T cell receptor activation prior to Foxp3 expression with only a small subset associated with several functionally important genes being exclusively Treg cell-specific. Thus, in a late cellular differentiation process Foxp3 defines Treg cell functionality in an ?opportunistic? manner by largely exploiting the preformed enhancer network instead of establishing a new enhancer landscape.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 23021222   Authors: Samstein RM,Arvey A,Josefowicz SZ,Peng X,Reynolds A,Sandstrom R,Neph S,Sabo P,Kim JM,Liao W,Li MO,Leslie C,Stamatoyannopoulos JA,Rudensky AY
Exact source GSE40685_2258_200_DN
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(show 49 gene sets from the same authors)
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Organism Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
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NCI-60 cell lines (National Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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