Systematic name M9920
Brief description Genes down-regulated in B lymphocytes with MAP3K7 [GeneID=6885] knockout: untreated versus anti IgM for 24h.
Full description or abstract The activation signaling of transcription factor nuclear factor-kB (NF-kB) plays central role for immune system. One of key kinase mediating this pathway is TAK1 in adaptive and innate immunity. However, role of TAK1 in B cell receptor signaling is still unclear. To know effects of TAK1-deletion on the gene expression induced by anti-IgM, we performed the time course analysis in comparison of wild type with TAK1-deleted splenic B cells.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 24833394   Authors: Shinohara H,Behar M,Inoue K,Hiroshima M,Yasuda T,Nagashima T,Kimura S,Sanjo H,Maeda S,Yumoto N,Ki S,Akira S,Sako Y,Hoffmann A,Kurosaki T,Okada-Hatakeyama M
Exact source GSE41176_3682_200_DN
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Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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