Human Gene Set: GSE41176_WT_VS_TAK1_KO_ANTI_IGM_STIM_BCELL_1H_DN


Standard name GSE41176_WT_VS_TAK1_KO_ANTI_IGM_STIM_BCELL_1H_DN
Systematic name M9935
Brief description Genes down-regulated in B lymphocytes treated by anti IgM for 1h: wildtype versus MAP3K7 [GeneID=6885] knockout.
Full description or abstract The activation signaling of transcription factor nuclear factor-kB (NF-kB) plays central role for immune system. One of key kinase mediating this pathway is TAK1 in adaptive and innate immunity. However, role of TAK1 in B cell receptor signaling is still unclear. To know effects of TAK1-deletion on the gene expression induced by anti-IgM, we performed the time course analysis in comparison of wild type with TAK1-deleted splenic B cells.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 24833394   Authors: Shinohara H,Behar M,Inoue K,Hiroshima M,Yasuda T,Nagashima T,Kimura S,Sanjo H,Maeda S,Yumoto N,Ki S,Akira S,Sako Y,Hoffmann A,Kurosaki T,Okada-Hatakeyama M
Exact source GSE41176_3684_200_DN
Related gene sets (show 25 additional gene sets from the source publication)

(show 83 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform or
identifier namespace
HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 200 genes
Gene families ? Categorize these 200 genes by gene family
Show members (show 200 source identifiers mapped to 200 genes)
Version history 7.3: Moved to ImmuneSigDB sub-collection.

We need your help: Update on GSEA/MSigDB funding support

Last November we submitted a proposal to NCI's Information Technology for Cancer Research (ITCR) program for the continued funding of GSEA and MSigDB. Unfortunately, our proposal was not funded in this round, but we were encouraged to resubmit for the next one. This funding is critical for our continuing support and enhancement of the GSEA-MSigDB resource.

For our original submission many of you sent us emails of support, an important requirement for these grants. We now ask for your help again. We would greatly appreciate a short email message from you describing how the resource has been of value to your work and any concerns you may have about its continued availability.

Please send us your message of support to gsea-los@broadinstitute.org on or before Monday June 5, 2023.

Thanks in advance for your help and support.
The GSEA/MSigDB Team.


See MSigDB license terms here. Please note that certain gene sets have special access terms.