Human Gene Set: GSE41176_WT_VS_TAK1_KO_ANTI_IGM_STIM_BCELL_1H_DN
Standard name
GSE41176_WT_VS_TAK1_KO_ANTI_IGM_STIM_BCELL_1H_DN
Systematic name
M9935
Brief description
Genes down-regulated in B lymphocytes treated by anti IgM for 1h: wildtype versus MAP3K7 [GeneID=6885] knockout.
Full description or abstract
The activation signaling of transcription factor nuclear factor-kB (NF-kB) plays central role for immune system. One of key kinase mediating this pathway is TAK1 in adaptive and innate immunity. However, role of TAK1 in B cell receptor signaling is still unclear. To know effects of TAK1-deletion on the gene expression induced by anti-IgM, we performed the time course analysis in comparison of wild type with TAK1-deleted splenic B cells.
