Human Gene Set: GSE41176_WT_VS_TAK1_KO_ANTI_IGM_STIM_BCELL_1H_DN
Standard name
GSE41176_WT_VS_TAK1_KO_ANTI_IGM_STIM_BCELL_1H_DN
Systematic name
M9935
Brief description
Genes down-regulated in B lymphocytes treated by anti IgM for 1h: wildtype versus MAP3K7 [GeneID=6885] knockout.
Full description or abstract
The activation signaling of transcription factor nuclear factor-kB (NF-kB) plays central role for immune system. One of key kinase mediating this pathway is TAK1 in adaptive and innate immunity. However, role of TAK1 in B cell receptor signaling is still unclear. To know effects of TAK1-deletion on the gene expression induced by anti-IgM, we performed the time course analysis in comparison of wild type with TAK1-deleted splenic B cells.
We need your help: Update on GSEA/MSigDB funding support
Last November we submitted a proposal to NCI's Information Technology for Cancer Research (ITCR) program for the continued
funding of GSEA and MSigDB. Unfortunately, our proposal was not funded in this round, but we were encouraged to resubmit
for the next one. This funding is critical for our continuing support and enhancement of the GSEA-MSigDB resource.
For our original submission many of you sent us emails of support, an important requirement for these grants. We
now ask for your help again. We would greatly appreciate a short email message from you describing how the resource
has been of value to your work and any concerns you may have about its continued availability.
