Human Gene Set: GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_DN


Standard name GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_DN
Systematic name M10002
Brief description Genes down-regulated in dendritic cells with IFNAR1 [GeneID=3454] knockout: CD8A [GeneID=925] versus ITGAM+ [GeneID=3684].
Full description or abstract Murine Cytomegalovirus (MCMV) infection leads to early activation of various immune cells, including B and T lymphocytes, before the actual initiation of antigen-specific adaptive immunity. This activation is partly driven by innate cytokines, including type I interferon (IFN), which are induced early after infection. The objective of this study was to address the role of type I IFN in shaping early/innate B and T cell responses to a primary acute viral infection. In order to decipher the specific impact of IFN-I on cell subsets, we performed a genome-wide expression analysis on WT splenic B and CD8 T lymphocytes isolated from C57BL/6 [CD45.1 WT / CD45.2 IFNAR-KO] mixed bone marrow chimera mice. This study complements series GSE39555, which focused on early responses of NK cells and of the two subsets of conventional dendritic cells.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
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Exact source GSE45365_3775_200_DN
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Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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