Human Gene Set: GSE7509_FCGRIIB_VS_TNFA_IL1B_IL6_PGE_STIM_DC_DN


Standard name GSE7509_FCGRIIB_VS_TNFA_IL1B_IL6_PGE_STIM_DC_DN
Systematic name M6824
Brief description Genes down-regulated in dendritic cells: anti-FcgRIIB versus inflammatory cytokine cocktail.
Full description or abstract The ability of dendritic cells (DCs) to activate immunity is linked to their maturation status. In prior studies we have shown that selective antibody-mediated blockade of inhibitory FcgRIIB receptor on human DCs in the presence of activating immunoglobulin (Ig) ligands leads to DC maturation and enhanced immunity to antibody-coated tumor cells. Here we show that Fcg receptor (FcgR) mediated activation of human monocytes and monocyte-derived DCs is associated with a distinct gene expression pattern, including several inflammation associated chemokines as well as type 1 interferon (IFN) response genes including the activation of signal transducer and activator of transcription 1 (STAT1).
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 17502666   Authors: Dhodapkar KM,Banerjee D,Connolly J,Kukreja A,Matayeva E,Veri MC,Ravetch JV,Steinman RM,Dhodapkar MV
Exact source GSE7509_3405_200_DN
Related gene sets (show 13 additional gene sets from the source publication)

(show 58 gene sets from any of these authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 154 genes
Gene families ? Categorize these 154 genes by gene family
Show members (show 200 source identifiers mapped to 154 genes)
Version history 7.3: Moved to ImmuneSigDB sub-collection.

See MSigDB license terms here. Please note that certain gene sets have special access terms.