Standard name |
HARALAMBIEVA_PBMC_FLUARIX_AGE_50_74YO_CORR_WITH_28D_MEM_B_CELL_RESPONSE_AT_28DY_LATE_GENE_EXPR_INDIVID_GENE_MODELS_PRED_PEAK_B_CELL_ELISPOT_RESP_NEGATIVE |
Systematic name |
M41091 |
Brief description |
Genes negatively correlated with memory B cell response at 28d in peripheral blood mononuclear cell in seniors (50-74) after exposure to Fluarix , time point 28D. Comment: D: Late gene expression individual gene models (predicting peak B cell ELISPOT response) for module 11 (D, MSE=2.062) |
Full description or abstract |
BACKGROUND: Studies suggest that the recall-based humoral immune responses to influenza A/H1N1 originates from activated memory B cells. The aim of this study was to identify baseline, early and late blood transcriptional signatures (in peripheral blood mononuclear cells/PBMCs) associated with memory B cell response following influenza vaccination. METHODS: We used pre- and post-vaccination mRNA-Seq transcriptional profiling on samples from 159 subjects (50-74years old) following receipt of seasonal trivalent influenza vaccine containing the A/California/7/2009/H1N1-like virus, and penalized regression modeling to identify associations with influenza A/H1N1-specific memory B cell ELISPOT response after vaccination. RESULTS: Genesets and genes (p-value range 7.92E(-08) to 0.00018, q-value range 0.00019-0.039) demonstrating significant associations (of gene expression levels) with memory B cell response suggest the importance of metabolic (cholesterol and lipid metabolism-related), cell migration/adhesion, MAP kinase, NF-kB cell signaling (chemokine/cytokine signaling) and transcriptional regulation gene signatures in the development of memory B cell response after influenza vaccination. CONCLUSION: Through an unbiased transcriptome-wide profiling approach, our study identified signatures of memory B cell response following influenza vaccination, highlighting the underappreciated role of metabolic changes (among the other immune function-related events) in the regulation of influenza vaccine-induced immune memory. |
Collection |
C7: Immunologic Signature VAX: HIPC Vaccine Response |
Source publication |
Pubmed 27317456 Authors: Haralambieva IH,Ovsyannikova IG,Kennedy RB,Zimmermann MT,Grill DE,Oberg AL,Poland GA |
Exact source |
Suppl Fig 1D |
Related gene sets |
(show 11 additional gene sets from the source publication)
(show 22 gene sets from the same authors)
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External links |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520794/bin/NIHMS880612-supplement-Supp_Fi...
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Filtered by similarity ?
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Source species |
Homo sapiens |
Contributed by |
HIPC SIGNATURES (NIAID/HIPC SIGNATURES) |
Source platform or identifier namespace |
HUMAN_GENE_SYMBOL |
Dataset references |
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GTEx compendium
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NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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these 10 genes
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10 genes by gene family
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Show members |
(show 10 source identifiers mapped to 10 genes)
Source Id |
NCBI (Entrez) Gene Id |
Gene Symbol |
Gene Description |
A1BG |
1 |
A1BG |
alpha-1-B glycoprotein [Source:HGNC Symb... |
CRB2 |
286204 |
CRB2 |
crumbs cell polarity complex component 2... |
DAB2 |
1601 |
DAB2 |
DAB adaptor protein 2 [Source:HGNC Symbo... |
IGSF10 |
285313 |
IGSF10 |
immunoglobulin superfamily member 10 [So... |
NFE2L3 |
9603 |
NFE2L3 |
NFE2 like bZIP transcription factor 3 [S... |
RAI1 |
10743 |
RAI1 |
retinoic acid induced 1 [Source:HGNC Sym... |
SNORA45 |
677826 |
SNORA3B |
small nucleolar RNA, H/ACA box 3B [Sourc... |
SNORD102 |
26771 |
SNORD102 |
small nucleolar RNA, C/D box 102 [Source... |
SYNJ1 |
8867 |
SYNJ1 |
synaptojanin 1 [Source:HGNC Symbol;Acc:H... |
ZNF682 |
91120 |
ZNF682 |
zinc finger protein 682 [Source:HGNC Sym... |
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Version history |
7.3: First Introduced.
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