Standard name |
HARALAMBIEVA_PBMC_FLUARIX_AGE_50_74YO_CORR_WITH_28D_MEM_B_CELL_RESPONSE_AT_28DY_LEUK_MIGR_MAPK_ACT_CYTOK_SIG_DIAB_OF_THE_YNG_NEGATIVE |
Systematic name |
M40893 |
Brief description |
Genes negatively correlated with memory B cell response at 28d in peripheral blood mononuclear cell in seniors (50-74) after exposure to Fluarix , time point 28D. Comment: selected pathways: leukocyte migration, MAP kinase activity, cytokine signaling, diabetes of the young |
Full description or abstract |
BACKGROUND: Studies suggest that the recall-based humoral immune responses to influenza A/H1N1 originates from activated memory B cells. The aim of this study was to identify baseline, early and late blood transcriptional signatures (in peripheral blood mononuclear cells/PBMCs) associated with memory B cell response following influenza vaccination. METHODS: We used pre- and post-vaccination mRNA-Seq transcriptional profiling on samples from 159 subjects (50-74years old) following receipt of seasonal trivalent influenza vaccine containing the A/California/7/2009/H1N1-like virus, and penalized regression modeling to identify associations with influenza A/H1N1-specific memory B cell ELISPOT response after vaccination. RESULTS: Genesets and genes (p-value range 7.92E(-08) to 0.00018, q-value range 0.00019-0.039) demonstrating significant associations (of gene expression levels) with memory B cell response suggest the importance of metabolic (cholesterol and lipid metabolism-related), cell migration/adhesion, MAP kinase, NF-kB cell signaling (chemokine/cytokine signaling) and transcriptional regulation gene signatures in the development of memory B cell response after influenza vaccination. CONCLUSION: Through an unbiased transcriptome-wide profiling approach, our study identified signatures of memory B cell response following influenza vaccination, highlighting the underappreciated role of metabolic changes (among the other immune function-related events) in the regulation of influenza vaccine-induced immune memory. |
Collection |
C7: Immunologic Signature VAX: HIPC Vaccine Response |
Source publication |
Pubmed 27317456 Authors: Haralambieva IH,Ovsyannikova IG,Kennedy RB,Zimmermann MT,Grill DE,Oberg AL,Poland GA |
Exact source |
Fig 2C-F; Table 2 |
Related gene sets |
(show 11 additional gene sets from the source publication)
(show 22 gene sets from the same authors)
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External links |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520794/table/T2/
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Filtered by similarity ?
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Source species |
Homo sapiens |
Contributed by |
HIPC SIGNATURES (NIAID/HIPC SIGNATURES) |
Source platform or identifier namespace |
HUMAN_GENE_SYMBOL |
Dataset references |
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Advanced query |
Further investigate
these 11 genes
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Gene families ? |
Categorize these
11 genes by gene family
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Show members |
(show 11 source identifiers mapped to 11 genes)
Source Id |
NCBI (Entrez) Gene Id |
Gene Symbol |
Gene Description |
AIMP1 |
9255 |
AIMP1 |
aminoacyl tRNA synthetase complex interactin... |
CCR2 |
729230 |
CCR2 |
C-C motif chemokine receptor 2 [Source:HGNC ... |
CKLF |
51192 |
CKLF |
chemokine like factor [Source:HGNC Symbol;Ac... |
COMMD7 |
149951 |
COMMD7 |
COMM domain containing 7 [Source:HGNC Symbol... |
DUOX1 |
53905 |
DUOX1 |
dual oxidase 1 [Source:HGNC Symbol;Acc:HGNC:... |
HNF1A |
6927 |
HNF1A |
HNF1 homeobox A [Source:HGNC Symbol;Acc:HGNC... |
MAPK1 |
5594 |
MAPK1 |
mitogen-activated protein kinase 1 [Source:H... |
MAPK11 |
5600 |
MAPK11 |
mitogen-activated protein kinase 11 [Source:... |
MAPK9 |
5601 |
MAPK9 |
mitogen-activated protein kinase 9 [Source:H... |
PAX6 |
5080 |
PAX6 |
paired box 6 [Source:HGNC Symbol;Acc:HGNC:8620] |
ZNF675 |
171392 |
ZNF675 |
zinc finger protein 675 [Source:HGNC Symbol;... |
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Version history |
7.3: First Introduced.
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