Human Gene Set: HOEGERKORP_CD44_TARGETS_DIRECT_DN


Standard name HOEGERKORP_CD44_TARGETS_DIRECT_DN
Systematic name M1823
Brief description Genes directly down-regulated by CD44 [GeneID=960] stimulation of B lymphocytes.
Full description or abstract A number of studies have implicated a role for the cell surface glycoprotein CD44 in several biologic events, such as lymphopoiesis, homing, lymphocyte activation, and apoptosis. We have earlier reported that signaling via CD44 on naive B cells in addition to B-cell receptor (BCR) and CD40 engagement generated a germinal center-like phenotype. To further characterize the global role of CD44 in B differentiation, we examined the expression profile of human B cells cultured in vitro in the presence or absence of CD44 ligation, together with anti-immunoglobulin (anti-Ig) and anti-CD40 antibodies. The data sets derived from DNA microarrays were analyzed using a novel statistical analysis scheme created to retrieve the most likely expression pattern of CD44 ligation. Our results show that genes such as interleukin-6 (IL-6), IL-1alpha, and beta(2)-adrenergic receptor (beta(2)-AR) were specifically up-regulated by CD44 ligation, suggesting a novel role for CD44 in immunoregulation and inflammation.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 12411303   Authors: Högerkorp CM,Bilke S,Breslin T,Ingvarsson S,Borrebaeck CA
Exact source Table 2
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(show 5 gene sets from the same authors)
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Organism Homo sapiens
Contributed by Kevin Vogelsang (MSigDB Team)
Source platform AFFY_HuGene
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Version history 3.0: Renamed from HOGERKORP_CD44_DN

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