Human Gene Set: HOFFMANN_PRE_BI_TO_LARGE_PRE_BII_LYMPHOCYTE_DN

For the Mouse gene set with the same name, see HOFFMANN_PRE_BI_TO_LARGE_PRE_BII_LYMPHOCYTE_DN

Standard name HOFFMANN_PRE_BI_TO_LARGE_PRE_BII_LYMPHOCYTE_DN
Systematic name M7405
Brief description Genes down-regulated during differentiation from pre-BI to large pre-BII lymphocyte.
Full description or abstract Gene expression profiles of five consecutive stages of mouse B cell development were generated with high-density oligonucleotide arrays from as few as 2 x 10(4) ex vivo isolated and flow-cytometrically purified cells. Between 2.8% and 6.8% of all genes change on differentiation from one cellular stage to the next by at least twofold. The entire pathway involves differential expression of 10.7% of all genes. Previously known expression patterns of 15 genes (like surrogate light chain, RAG-1/2, MHC class II, mel-14 antigen) are confirmed. The gene expression patterns of the proliferating pre-BI and large pre-BII cells on the one hand, and the resting immature and mature B cells on the other hand, are most similar to each other. Small pre-BII cells display a pattern that is transitional between these two groups. Most of the genes expressed in early precursors are involved in general processes, like protein folding or cell cycle regulation, whereas more mature precursors express genes involved in more specific molecular programs (cell surface receptors, secreted factors, and adhesion molecules, among others). Between 19 and 139 genes share a given expression pattern. Combining knowledge about gene function and expression pattern allows identification of novel candidate genes potentially involved in self-maintenance of pre-BI cells, allelic exclusion and pre-B cell receptor signaling in large pre BII cells, cell-cycle arrest of small pre-BII cells, propensity toward apoptosis or anergization in immature B cells, propensity toward cell division and activation in mature B cells, and stage-specific interactions with stromal cells in the bone marrow.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 11779835   Authors: Hoffmann R,Seidl T,Neeb M,Rolink A,Melchers F
Exact source Table 2S: CHGF_PRE_LAR<=-4
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Source species Mus musculus
Contributed by Arthur Liberzon (MSigDB Team)
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identifier namespace		 AFFY_Mu11K
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