Systematic name M41187
Brief description Genes down-regulated in CD4-positive, alpha-beta memory T cell 7d vs 0d in adults (18-45) after exposure to BCG vaccine , time point 7D , administered PO (oral). Comment: top 100 most significantly altered genes comparing Day 0 and Day 7 responses directly ex vivo
Full description or abstract Protective efficacy of Bacillus Calmette-Guerin (BCG) may be affected by the methods and routes of vaccine administration. We have studied the safety and immunogenicity of oral (PO) and/or intradermal (ID) administration of BCG in healthy human subjects. No major safety concerns were detected in the 68 healthy adults vaccinated with PO and/or ID BCG. Although both PO and ID BCG could induce systemic Th1 responses capable of IFN-gamma production, ID BCG more strongly induced systemic Th1 responses. In contrast, stronger mucosal responses (TB-specific secretory IgA and bronchoalveolar lavage T cells) were induced by PO BCG vaccination. To generate preliminary data comparing the early gene signatures induced by mucosal and systemic BCG vaccination, CD4+ memory T cells were isolated from subsets of BCG vaccinated subjects pre- (Day 0) and post-vaccination (Days 7 and 56), rested or stimulated with BCG infected dendritic cells, and then studied by Illumina BeadArray transcriptomal analysis. Notably, distinct gene expression profiles were identified both on Day 7 and Day 56 comparing the PO and ID BCG vaccinated groups by GSEA analysis. Future correlation analyses between specific gene expression patterns and distinct mucosal and systemic immune responses induced will be highly informative for TB vaccine development.
Collection C7: Immunologic Signature
      VAX: HIPC Vaccine Response
Source publication Pubmed 28853442   Authors: Hoft DF,Xia M,Zhang GL,Blazevic A,Tennant J,Kaplan C,Matuschak G,Dube TJ,Hill H,Schlesinger LS,Andersen PL,Brusic V
Exact source Fig 6A (PO)
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