Standard name |
HOLLEMAN_ASPARAGINASE_RESISTANCE_B_ALL_DN |
Systematic name |
M2554 |
Brief description |
Genes distinguishing asparaginase resistant and sensitive B-lineage ALL; here - genes down-regulated in the drug resistant samples. |
Full description or abstract |
Childhood acute lymphoblastic leukemia (ALL) is curable with chemotherapy in approximately 80 percent of patients. However, the cause of treatment failure in the remaining 20 percent of patients is largely unknown. |
Collection |
C2: Curated CGP: Chemical and Genetic Perturbations |
Source publication |
Pubmed 15295046 Authors: Holleman A,Cheok MH,den Boer ML,Yang W,Veerman AJ,Kazemier KM,Pei D,Cheng C,Pui CH,Relling MV,Janka-Schaub GE,Pieters R,Evans WE |
Exact source |
Fig. 7S: R/S ratio < 1 |
Related gene sets |
(show 15 additional gene sets from the source publication)
(show 28 gene sets from the same authors)
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External links |
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Filtered by similarity ?
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Source species |
Homo sapiens |
Contributed by |
Arthur Liberzon (MSigDB Team) |
Source platform or identifier namespace |
AFFY_HG_U133 |
Dataset references |
(show 1 datasets)
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Download gene set |
format: grp | gmt | xml | json | TSV metadata |
Compute overlaps ? |
(show collections to investigate for overlap with this gene set)
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Compendia expression profiles ? |
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Advanced query |
Further investigate
these 15 genes
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Gene families ? |
Categorize these
15 genes by gene family
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Show members |
(show 17 source identifiers mapped to 15 genes)
Source Id |
NCBI (Entrez) Gene Id |
Gene Symbol |
Gene Description |
201015_s_at |
3728 |
JUP |
junction plakoglobin [Source:HGNC Sym... |
201140_s_at |
5878 |
RAB5C |
RAB5C, member RAS oncogene family [So... |
201156_s_at |
5878 |
RAB5C |
RAB5C, member RAS oncogene family [So... |
203274_at |
8263 |
F8A1 |
coagulation factor VIII associated 1 ... |
203311_s_at |
382 |
ARF6 |
ADP ribosylation factor 6 [Source:HGN... |
203388_at |
409 |
ARRB2 |
arrestin beta 2 [Source:HGNC Symbol;A... |
203521_s_at |
24149 |
ZNF318 |
zinc finger protein 318 [Source:HGNC ... |
208579_x_at |
54145 |
H2BC12L |
H2B clustered histone 12 like [Source... |
209806_at |
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211559_s_at |
901 |
CCNG2 |
cyclin G2 [Source:HGNC Symbol;Acc:HGN... |
212070_at |
9289 |
ADGRG1 |
adhesion G protein-coupled receptor G... |
212643_at |
93487 |
MAPK1IP1L |
mitogen-activated protein kinase 1 in... |
217750_s_at |
65264 |
UBE2Z |
ubiquitin conjugating enzyme E2 Z [So... |
218333_at |
51009 |
DERL2 |
derlin 2 [Source:HGNC Symbol;Acc:HGNC... |
218669_at |
57826 |
RAP2C |
RAP2C, member of RAS oncogene family ... |
221760_at |
4121 |
MAN1A1 |
mannosidase alpha class 1A member 1 [... |
221773_at |
2004 |
ELK3 |
ETS transcription factor ELK3 [Source... |
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Version history |
3.1: First introduced
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We need your help: Update on GSEA/MSigDB funding support
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