Human Gene Set: HOLLEMAN_VINCRISTINE_RESISTANCE_ALL_DN


Standard name HOLLEMAN_VINCRISTINE_RESISTANCE_ALL_DN
Systematic name M2562
Brief description Genes distinguishing vincristine [PubChem=5978] resistant and sensitive ALL (B- and T-lineage ALL); here - genes down-regulated in the drug resistant samples.
Full description or abstract Childhood acute lymphoblastic leukemia (ALL) is curable with chemotherapy in approximately 80 percent of patients. However, the cause of treatment failure in the remaining 20 percent of patients is largely unknown.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 15295046   Authors: Holleman A,Cheok MH,den Boer ML,Yang W,Veerman AJ,Kazemier KM,Pei D,Cheng C,Pui CH,Relling MV,Janka-Schaub GE,Pieters R,Evans WE
Exact source Fig. 10S: R/S ratio < 1
Related gene sets (show 15 additional gene sets from the source publication)

(show 28 gene sets from the same authors)
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Source species Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
Source platform or
identifier namespace		 AFFY_HG_U133
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Version history 3.1: First introduced

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