Human Gene Set: HP_ABNORMAL_NAIVE_CD8_T_CELL_PROPORTION


Standard name HP_ABNORMAL_NAIVE_CD8_T_CELL_PROPORTION
Systematic name M50091
Brief description Abnormal naive CD8 T cell proportion
Full description or abstract Abnormal increase or decrease of the naive CD8+ T cell subpopulation, commonly characterized as CD45RA+, CD45RO-, or CD27+, measured as percentage of total CD8+ T cells in the blood, compared to a reference range for a given sex and age-group. These cells are sometimes also characterized as CD62L+ and CCR7+. [PMID:26700072]
Collection C5: Ontology
      HPO: Human Phenotype Ontology
Source publication  
Exact source HP:0410374
Related gene sets  
External links https://hpo.jax.org/app/browse/term/HP:0410374
Filtered by similarity ?
Source species Homo sapiens
Contributed by Human Phenotype Ontology Group (The Jackson Laboratory (JAX))
Source platform or
identifier namespace		 Human_NCBI_Gene_ID
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 5 genes
Gene families ? Categorize these 5 genes by gene family
Show members (show 5 source identifiers mapped to 5 genes)
Version history 2025.1.Hs: Updated to HPO Release 2025-05-06.

See MSigDB license terms here. Please note that certain gene sets have special access terms.