Human Gene Set: HP_DECREASED_CIRCULATING_TERMINAL_COMPLEMENT_COMPONENT_CONCENTRATION


Standard name HP_DECREASED_CIRCULATING_TERMINAL_COMPLEMENT_COMPONENT_CONCENTRATION
Systematic name M41572
Brief description Decreased circulating terminal complement component concentration
Full description or abstract Concentration below the lower limit of normal of one or more components of the the terminal membrane attack complex (MAC) portion of complement, which represents the lytic, pore-forming part of the system. The MAC comprises seven components: C5b, C6, C7, C8 (a heterotrimer composed of C8alpha, C8beta and C8gamma) and multiple copies of C9. [PMID:26841934]
Collection C5: Ontology
      HPO: Human Phenotype Ontology
Source publication  
Exact source HP:0033057
Related gene sets  
External links https://hpo.jax.org/app/browse/term/HP:0033057
Filtered by similarity ?
Source species Homo sapiens
Contributed by Human Phenotype Ontology Group (The Jackson Laboratory (JAX))
Source platform or
identifier namespace		 Human_NCBI_Gene_ID
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 6 genes
Gene families ? Categorize these 6 genes by gene family
Show members (show 6 source identifiers mapped to 6 genes)
Version history 2023.2.Hs: Renamed from HP_DECREASED_SERUM_TERMINAL_COMPLEMENT_COMPONENT.

See MSigDB license terms here. Please note that certain gene sets have special access terms.