Human Gene Set: HP_DECREASED_CLASS_SWITCHED_MEMORY_B_CELL_PROPORTION


Standard name HP_DECREASED_CLASS_SWITCHED_MEMORY_B_CELL_PROPORTION
Systematic name M50000
Brief description Decreased class-switched memory B cell proportion
Full description or abstract A reduction in the normal proportion of class-switched memory B cells (CD19+/CD27+/IgM+/IgD+) relative to the total number of B cells. Marginal zone B cells undergo limited somatic hypermutation and produce high-affinity IgM and some IgG, whereas class-switched memory B cells synthetize IgG, IgM, and IgA. [https://orcid.org/0000-0002-0736-9199]
Collection C5: Ontology
      HPO: Human Phenotype Ontology
Source publication  
Exact source HP:0030388
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External links https://hpo.jax.org/app/browse/term/HP:0030388
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Source species Homo sapiens
Contributed by Human Phenotype Ontology Group (The Jackson Laboratory (JAX))
Source platform or
identifier namespace		 Human_NCBI_Gene_ID
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Version history 2025.1.Hs: Updated to HPO Release 2025-05-06.

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