Human Gene Set: HP_IMPAIRED_PHYTOHEMAGGLUTININ_INDUCED_T_LYMPHOCYTE_TRANSFORMATION


Standard name HP_IMPAIRED_PHYTOHEMAGGLUTININ_INDUCED_T_LYMPHOCYTE_TRANSFORMATION
Systematic name M51883
Brief description Impaired phytohemagglutinin-induced T lymphocyte transformation
Full description or abstract Def: A reduced rate of T lymphocyte transformation in response to in vitro stimulation to the mitogen phytohemagglutinin (PHA). Following PHA stimulation, T cells normally undergo morphological and biochemical alterations that reflect the transformation into lymphoblasts. There are several methods for quantifying this effect including measuring the uptake of the radioactive marker 3H-TdR, methyl thiazolyl tetrazolium colorimetric analysis (MTT assay), and morphological examination under the microscope or using a hematology analyzer. Various types of stimulation index compare the amount of proliferation between treated and control cells. An impaired test refers to a result in which the amount of stimulation is subnormal. [PMID:36393975]
Collection C5: Ontology
      HPO: Human Phenotype Ontology
Source publication  
Exact source HP:0025834
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External links https://hpo.jax.org/app/browse/term/HP:0025834
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Source species Homo sapiens
Contributed by Human Phenotype Ontology Group (The Jackson Laboratory (JAX))
Source platform or
identifier namespace		 Human_NCBI_Gene_ID
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Version history 2026.2.Hs: Updated to HPO Release 2026-09-01.


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