Human Gene Set: HP_INTERNALLY_NUCLEATED_SKELETAL_MUSCLE_FIBERS
Standard name
HP_INTERNALLY_NUCLEATED_SKELETAL_MUSCLE_FIBERS
Systematic name
M41536
Brief description
Internally nucleated skeletal muscle fibers
Full description or abstract
An abnormally increased proportion of nuclei of sarcomeres with an internal localization. Individual muscle fibers are syncytia, formed by embryonic fusion of many myoblasts or later, myosatellite cells. Each muscle fiber contains many nuclei, peripherally positioned immediately adjacent to the sarcolemmal membrane. In healthy muscle only 3-5% of fibers contain nuclei that are located internally, within the cell, but many disease processes lead to internal nuclei. [PMID:22938878]
