Human Gene Set: IWANAGA_CARCINOGENESIS_BY_KRAS_DN

For the Mouse gene set with the same name, see IWANAGA_CARCINOGENESIS_BY_KRAS_DN

Standard name IWANAGA_CARCINOGENESIS_BY_KRAS_DN
Systematic name M9362
Brief description Cluster 4: genes down-regulated in lung tissue samples from mice with tumor-bearing genotypes (activated KRAS [GeneID=3845] alone or together with inactivated PTEN [GeneID=5728]).
Full description or abstract Phosphatase and tensin homologue deleted from chromosome 10 (Pten) is expressed aberrantly in non-small cell lung cancer cells, but the role of Pten in lung neoplasia has not been fully elucidated. In this study, we used a genetic approach to inactivate Pten in the bronchial epithelium of mice. Although, by itself, Pten inactivation had no discernible effect on bronchial epithelial histology, it accelerated lung tumorigenesis initiated by oncogenic K-ras, causing more rapid lethality than that induced by oncogenic K-ras alone (8 weeks versus 24 weeks of median duration of survival, respectively). Lung tumors arose in K-ras mutant, Pten-deficient mice that rapidly obstructed bronchial lumina and replaced alveolar spaces. Relative to K-ras mutant tumors, the K-ras mutant, Pten-deficient tumors exhibited more advanced histologic severity and more prominent inflammation and vascularity. Thus, Pten inactivation cooperated with oncogenic K-ras in promoting lung tumorigenesis.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 18281487   Authors: Iwanaga K,Yang Y,Raso MG,Ma L,Hanna AE,Thilaganathan N,Moghaddam S,Evans CM,Li H,Cai WW,Sato M,Minna JD,Wu H,Creighton CJ,Demayo FJ,Wistuba II,Kurie JM
Exact source Table 3S: cluster 4
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Source species Mus musculus
Contributed by Jessica Robertson (MSigDB Team)
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identifier namespace		 AFFY_Mouse430
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Version history 3.0: First introduced

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