Human Gene Set: KEGG_MEDICUS_REFERENCE_CA2_PYK2_RAS_ERK_SIGNALING_PATHWAY


Standard name KEGG_MEDICUS_REFERENCE_CA2_PYK2_RAS_ERK_SIGNALING_PATHWAY
Systematic name M47592
Brief description Pathway Definition from KEGG: Ca2+ -> PTK2B -> SRC -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
Full description or abstract Ca2+-PYK2-RAS-ERK signaling pathway. Pathway ID: N00538. Pathway type: Reference. Pathway class: nt06263 Hepatocellular carcinoma.
Collection C2: Curated
      CP: Canonical Pathways
            CP:KEGG_MEDICUS: KEGG Medicus Pathways
Source publication  
Exact source N00538
Related gene sets  
External links https://www.kegg.jp/entry/N00538
Filtered by similarity ?
Source species Homo sapiens
Contributed by Anthony Castanza (MSigDB Team)
Source platform or
identifier namespace
Human_NCBI_Gene_ID
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 15 genes
Gene families ? Categorize these 15 genes by gene family
Show members (show 15 source identifiers mapped to 15 genes)
Version history 2026.2.Hs: Updated to network file last modified on 2026-07-23


Creative Commons Attribution 4.0 International License (CC-BY-4.0)

The contents of this gene set are protected by copyright (c) 2004-2026 Broad Institute, Inc., Massachusetts Institute of Technology, and Regents of the University of California, subject to the terms and conditions of the Creative Commons Attribution 4.0 International License.

See the full MSigDB license terms here.