login
register
GSEA Home
Downloads
Molecular Signatures Database
Documentation
Contact
Team
MSigDB Home
Human Collections
About
Browse
Search
Investigate
Gene Families
Mouse Collections
About
Browse
Search
Investigate
Help
Human Gene Set: KEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_PI3K_SIGNALING_PATHWAY
Standard name
KEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_PI3K_SIGNALING_PATHWAY
Systematic name
M47405
Brief description
Pathway Definition from KEGG: BCR-ABL -> (CRKL+CBL+CRK) -> PI3K -> PIP3 -> AKT -| BAD
Full description or abstract
BCR-ABL fusion kinase to PI3K signaling pathway. Pathway ID: N00048. Pathway type: Variant. Pathway class: nt06276 Chronic myeloid leukemia.
Collection
C2: Curated
CP: Canonical Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
Source publication
Exact source
N00048
Related gene sets
External links
https://www.kegg.jp/entry/N00048
Filtered by similarity
?
Source species
Homo sapiens
Contributed by
KEGG (Kyoto Encyclopedia of Genes and Genomes)
Source platform or
identifier namespace
Human_NCBI_Gene_ID
Dataset references
Download gene set
format:
grp
|
gmt
|
xml
|
json
|
TSV metadata
Compute overlaps
?
(
show
collections to investigate for overlap with this gene set)
H: Hallmark
C1: Positional
C2: Curated
CGP: Chemical and Genetic Perturbations
CP: Canonical Pathways
CP:BIOCARTA: BioCarta Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
CP:PID: PID Pathways
CP:REACTOME: Reactome Pathways
CP:WIKIPATHWAYS: WikiPathways
CP:KEGG_LEGACY: KEGG Legacy Pathways
C3: Regulatory Target
MIR: microRNA Targets
MIR:MIRDB: miRDB
MIR:MIR_LEGACY: MIR_Legacy
TFT: Transcription Factor Targets
TFT:GTRD: GTRD
TFT:TFT_LEGACY: TFT_Legacy
C4: Computational
3CA: Curated Cancer Cell Atlas gene sets
CGN: Cancer Gene Neighborhoods
CM: Cancer Modules
C5: Ontology
GO: Gene Ontology
GO:BP: GO Biological Process
GO:CC: GO Cellular Component
GO:MF: GO Molecular Function
HPO: Human Phenotype Ontology
C6: Oncogenic Signature
C7: Immunologic Signature
IMMUNESIGDB: ImmuneSigDB
VAX: HIPC Vaccine Response
C8: Cell Type Signature
Compendia expression profiles
?
NG-CHM interactive heatmaps
(
Please note that clustering takes a few seconds
)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query
Further investigate
these 11 genes
Gene families
?
Categorize
these 11 genes by gene family
Show members
(
show
11 source identifiers mapped to 11 genes)
Source
Id
NCBI (Entrez)
Gene Id
Gene
Symbol
Gene
Description
10000
10000
AKT3
AKT serine/threonine kinase 3 [Source:HGNC Sym...
1398
1398
CRK
CRK proto-oncogene, adaptor protein [Source:HG...
1399
1399
CRKL
CRK like proto-oncogene, adaptor protein [Sour...
207
207
AKT1
AKT serine/threonine kinase 1 [Source:HGNC Sym...
208
208
AKT2
AKT serine/threonine kinase 2 [Source:HGNC Sym...
25
25
ABL1
ABL proto-oncogene 1, non-receptor tyrosine ki...
5290
5290
PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase...
5291
5291
PIK3CB
phosphatidylinositol-4,5-bisphosphate 3-kinase...
5293
5293
PIK3CD
phosphatidylinositol-4,5-bisphosphate 3-kinase...
572
572
BAD
BCL2 associated agonist of cell death [Source:...
867
867
CBL
Cbl proto-oncogene [Source:HGNC Symbol;Acc:HGN...
Version history
2023.2.Hs: First Introduced.
See
MSigDB license terms here
. Please note that certain gene sets have special access terms.