login
register
GSEA Home
Downloads
Molecular Signatures Database
Documentation
Contact
Team
MSigDB Home
Human Collections
About
Browse
Search
Investigate
Gene Families
Mouse Collections
About
Browse
Search
Investigate
Help
Human Gene Set: KRAS.600.LUNG.BREAST_UP.V1_DN
Standard name
KRAS.600.LUNG.BREAST_UP.V1_DN
Systematic name
M2885
Brief description
Genes down-regulated in epithelial lung and breast cancer cell lines over-expressing an oncogenic form of KRAS
[GeneID=3845]
gene.
Full description or abstract
Collection
C6: Oncogenic Signature
Source publication
Authors: Boehm JS
Exact source
AALE-KRAS vs AALE-Vector: top 300 genes (diff. of means)
Related gene sets
(
show
27 gene sets from any of these authors)
FIRESTEIN_CTNNB1_PATHWAY
FIRESTEIN_CTNNB1_PATHWAY_AND_PROLIFERATION
FIRESTEIN_PROLIFERATION
KRAS.300_UP.V1_DN
KRAS.300_UP.V1_UP
KRAS.50_UP.V1_DN
KRAS.50_UP.V1_UP
KRAS.600.LUNG.BREAST_UP.V1_UP
KRAS.600_UP.V1_DN
KRAS.600_UP.V1_UP
KRAS.AMP.LUNG_UP.V1_DN
KRAS.AMP.LUNG_UP.V1_UP
KRAS.BREAST_UP.V1_DN
KRAS.BREAST_UP.V1_UP
KRAS.DF.V1_DN
KRAS.DF.V1_UP
NFE2L2.V2
STK33_DN
STK33_NOMO_DN
STK33_NOMO_UP
STK33_SKM_DN
STK33_SKM_UP
STK33_UP
TBK1.DF_DN
TBK1.DF_UP
TBK1.DN.48HRS_DN
TBK1.DN.48HRS_UP
External links
Filtered by similarity
?
Source species
Homo sapiens
Contributed by
Pablo Tamayo (Broad Institute)
Source platform or
identifier namespace
HUMAN_GENE_SYMBOL
Dataset references
Download gene set
format:
grp
|
gmt
|
xml
|
json
|
TSV metadata
Compute overlaps
?
(
show
collections to investigate for overlap with this gene set)
H: Hallmark
C1: Positional
C2: Curated
CGP: Chemical and Genetic Perturbations
CP: Canonical Pathways
CP:BIOCARTA: BioCarta Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
CP:PID: PID Pathways
CP:REACTOME: Reactome Pathways
CP:WIKIPATHWAYS: WikiPathways
CP:KEGG_LEGACY: KEGG Legacy Pathways
C3: Regulatory Target
MIR: microRNA Targets
MIR:MIRDB: miRDB
MIR:MIR_LEGACY: MIR_Legacy
TFT: Transcription Factor Targets
TFT:GTRD: GTRD
TFT:TFT_LEGACY: TFT_Legacy
C4: Computational
3CA: Curated Cancer Cell Atlas gene sets
CGN: Cancer Gene Neighborhoods
CM: Cancer Modules
C5: Ontology
GO: Gene Ontology
GO:BP: GO Biological Process
GO:CC: GO Cellular Component
GO:MF: GO Molecular Function
HPO: Human Phenotype Ontology
C6: Oncogenic Signature
C7: Immunologic Signature
IMMUNESIGDB: ImmuneSigDB
VAX: HIPC Vaccine Response
C8: Cell Type Signature
Compendia expression profiles
?
NG-CHM interactive heatmaps
(
Please note that clustering takes a few seconds
)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query
Further investigate
these 285 genes
Gene families
?
Categorize
these 285 genes by gene family
Show members
(
show
300 source identifiers mapped to 285 genes)
Source
Id
NCBI (Entrez)
Gene Id
Gene
Symbol
Gene
Description
AAAS
8086
AAAS
aladin WD repeat nucle...
ABHD9
79852
EPHX3
epoxide hydrolase 3 [S...
ACCN2
41
ASIC1
acid sensing ion chann...
ADAMTS20
80070
ADAMTS20
ADAM metallopeptidase ...
ADD2
119
ADD2
adducin 2 [Source:HGNC...
ADORA3
140
ADORA3
adenosine A3 receptor ...
AKAP6
9472
AKAP6
A-kinase anchoring pro...
AKR1B10
57016
AKR1B10
aldo-keto reductase fa...
ALDH5A1
7915
ALDH5A1
aldehyde dehydrogenase...
ALOX12B
242
ALOX12B
arachidonate 12-lipoxy...
AMBN
258
AMBN
ameloblastin [Source:H...
ANKRD1
27063
ANKRD1
ankyrin repeat domain ...
APC2
10297
APC2
APC regulator of WNT s...
APOB
338
APOB
apolipoprotein B [Sour...
APOL3
80833
APOL3
apolipoprotein L3 [Sou...
ART1
417
ART1
ADP-ribosyltransferase...
ATHL1
80162
PGGHG
protein-glucosylgalact...
ATP6V1B1
525
ATP6V1B1
ATPase H+ transporting...
BBOX1
8424
BBOX1
gamma-butyrobetaine hy...
BDKRB1
623
BDKRB1
bradykinin receptor B1...
BRDT
676
BRDT
bromodomain testis ass...
BTN3A2
11118
BTN3A2
butyrophilin subfamily...
C17orf80
55028
MTNAP1
mitochondrial nucleoid...
C1R /// LOC64367
6
C20orf39
79953
SYNDIG1
synapse differentiatio...
C22orf31
25770
C22orf31
chromosome 22 open rea...
C6orf10
10665
TSBP1
testis expressed basic...
C6orf64
55776
SAYSD1
SAYSVFN motif domain c...
C9orf127
51754
TMEM8B
transmembrane protein ...
C9orf39
54875
CNTLN
centlein [Source:HGNC ...
C9orf61
9413
ENTREP1
endosomal transmembran...
CA5B
11238
CA5B
carbonic anhydrase 5B ...
CACNA1I
8911
CACNA1I
calcium voltage-gated ...
CACNA2D3
55799
CACNA2D3
calcium voltage-gated ...
CALCB
797
CALCB
calcitonin related pol...
CALML3
810
CALML3
calmodulin like 3 [Sou...
CALML5
51806
CALML5
calmodulin like 5 [Sou...
CCDC102B
79839
CCDC102B
coiled-coil domain con...
CCDC121
79635
CCDC121
coiled-coil domain con...
CCDC132
55610
VPS50
VPS50 subunit of EARP/...
CD207
50489
CD207
CD207 molecule [Source...
CD248
57124
CD248
CD248 molecule [Source...
CD36
948
CD36
CD36 molecule (CD36 bl...
CD5
921
CD5
CD5 molecule [Source:H...
CD6
923
CD6
CD6 molecule [Source:H...
CDH12
1010
CDH12
cadherin 12 [Source:HG...
CDH16
1014
CDH16
cadherin 16 [Source:HG...
CHRM5
1133
CHRM5
cholinergic receptor m...
CIITA
4261
CIITA
class II major histoco...
CKM
1158
CKM
creatine kinase, M-typ...
CLCA2
9635
CLCA2
chloride channel acces...
CLDN16
10686
CLDN16
claudin 16 [Source:HGN...
CLDN8
9073
CLDN8
claudin 8 [Source:HGNC...
COBL
23242
COBL
cordon-bleu WH2 repeat...
COL19A1
1310
COL19A1
collagen type XIX alph...
COL2A1
1280
COL2A1
collagen type II alpha...
COL5A2
1290
COL5A2
collagen type V alpha ...
COL5A3
50509
COL5A3
collagen type V alpha ...
CPB1
1360
CPB1
carboxypeptidase B1 [S...
CRABP1
1381
CRABP1
cellular retinoic acid...
CRABP2
1382
CRABP2
cellular retinoic acid...
CREB3L1
90993
CREB3L1
cAMP responsive elemen...
CRYAB
1410
CRYAB
crystallin alpha B [So...
CXCL14
9547
CXCL14
C-X-C motif chemokine ...
CXCR7
57007
ACKR3
atypical chemokine rec...
CYP21A2
1589
CYP21A2
cytochrome P450 family...
CYP26B1
56603
CYP26B1
cytochrome P450 family...
DAAM2
23500
DAAM2
dishevelled associated...
DEFB1
1672
DEFB1
defensin beta 1 [Sourc...
DENND1C
79958
DENND1C
DENN domain containing...
DENND2D
79961
DENND2D
DENN domain containing...
DFNB31
25861
WHRN
whirlin [Source:HGNC S...
DGCR6L
85359
DGCR6L
DiGeorge syndrome crit...
DKFZp434A0131
54441
STAG3L1
STAG3 cohesin complex ...
DKFZp434O047
26083
TBC1D29P
TBC1 domain family mem...
DLX6
1750
DLX6
distal-less homeobox 6...
DPT
1805
DPT
dermatopontin [Source:...
DPYS
1807
DPYS
dihydropyrimidinase [S...
DTNB
1838
DTNB
dystrobrevin beta [Sou...
DTX2
113878
DTX2
deltex E3 ubiquitin li...
DUSP21
63904
DUSP21
dual specificity phosp...
DYRK1B
9149
DYRK1B
dual specificity tyros...
ELMO1
9844
ELMO1
engulfment and cell mo...
EMID1
129080
EMID1
EMI domain containing ...
EMR1
2015
ADGRE1
adhesion G protein-cou...
ENTPD5
957
ENTPD5
ectonucleoside triphos...
EPB41L4A
64097
EPB41L4A
erythrocyte membrane p...
EPHX2
2053
EPHX2
epoxide hydrolase 2 [S...
FBXO24
26261
FBXO24
F-box protein 24 [Sour...
FGF1
2246
FGF1
fibroblast growth fact...
FGF21
26291
FGF21
fibroblast growth fact...
FGFR3
2261
FGFR3
fibroblast growth fact...
FLJ10159
55084
SOBP
sine oculis binding pr...
FLJ10490
55150
C19orf73
chromosome 19 open rea...
FLJ10916
55258
THNSL2
threonine synthase lik...
FLJ10986
55277
FGGY
FGGY carbohydrate kina...
FLJ22531
79703
TOP6BL
TOP6B like initiator o...
FLJ22662
79887
PLBD1
phospholipase B domain...
FLT1
2321
FLT1
fms related receptor t...
FMO6
388714
FMO6P
flavin containing dime...
FRAS1
80144
FRAS1
Fraser extracellular m...
FSCN2
25794
FSCN2
fascin actin-bundling ...
GABRA4
2557
GABRA4
gamma-aminobutyric aci...
GADD45G
10912
GADD45G
growth arrest and DNA ...
GALNT8
26290
GALNT8
polypeptide N-acetylga...
GAMT
2593
GAMT
guanidinoacetate N-met...
GAS1
2619
GAS1
growth arrest specific...
GBP1
2633
GBP1
guanylate binding prot...
GBP2
2634
GBP2
guanylate binding prot...
GDNF
2668
GDNF
glial cell derived neu...
GLS2
27165
GLS2
glutaminase 2 [Source:...
GLYAT
10249
GLYAT
glycine-N-acyltransfer...
GOLGA /// GOLGA6
///
GP1BA
2811
GP1BA
glycoprotein Ib platel...
GP1BB
2812
GP1BB
glycoprotein Ib platel...
GP6
51206
GP6
glycoprotein VI platel...
GPR77
27202
C5AR2
complement C5a recepto...
GPRC5B
51704
GPRC5B
G protein-coupled rece...
GRIA1
2890
GRIA1
glutamate ionotropic r...
HBZ
3050
HBZ
hemoglobin subunit zet...
HCN2
610
HCN2
hyperpolarization acti...
HEPH
9843
HEPH
hephaestin [Source:HGN...
HHLA1
10086
HHLA1
HHLA1 neighbor of OC90...
HIST1H3A
8350
H3C1
H3 clustered histone 1...
HOXB3
3213
HOXB3
homeobox B3 [Source:HG...
HRK
8739
HRK
harakiri, BCL2 interac...
HTR1B
3351
HTR1B
5-hydroxytryptamine re...
HTR1D
3352
HTR1D
5-hydroxytryptamine re...
HTR1E
3354
HTR1E
5-hydroxytryptamine re...
IFI44L
10964
IFI44L
interferon induced pro...
IFNA16
3449
IFNA16
interferon alpha 16 [S...
IFT140
9742
IFT140
intraflagellar transpo...
IGF2AS
51214
IGF2-AS
IGF2 antisense RNA [So...
IGFBP2
3485
IGFBP2
insulin like growth fa...
IL12A
3592
IL12A
interleukin 12A [Sourc...
IL12RB2
3595
IL12RB2
interleukin 12 recepto...
IL18R1
8809
IL18R1
interleukin 18 recepto...
IL22
50616
IL22
interleukin 22 [Source...
IL5
3567
IL5
interleukin 5 [Source:...
IL5RA
3568
IL5RA
interleukin 5 receptor...
IL8RA
3577
CXCR1
C-X-C motif chemokine ...
IMPA2
3613
IMPA2
inositol monophosphata...
INPP5D
3635
INPP5D
inositol polyphosphate...
IQCG
84223
IQCG
IQ motif containing G ...
IVL
3713
IVL
involucrin [Source:HGN...
KCNB1
3745
KCNB1
potassium voltage-gate...
KCNIP2
30819
KCNIP2
potassium voltage-gate...
KCNMB1
3779
KCNMB1
potassium calcium-acti...
KCNMB2
10242
KCNMB2
potassium calcium-acti...
KIAA1305
57523
NYNRIN
NYN domain and retrovi...
KIAA1456
57604
TRMT9B
tRNA methyltransferase...
KIAA1660
KIF25
3834
KIF25
kinesin family member ...
KLF8
11279
KLF8
KLF transcription fact...
KLK12
43849
KLK12
kallikrein related pep...
KLRK1
22914
KLRK1
killer cell lectin lik...
KRT1
3848
KRT1
keratin 1 [Source:HGNC...
KRT13
3860
KRT13
keratin 13 [Source:HGN...
KRT16
3868
KRT16
keratin 16 [Source:HGN...
KRT20
54474
KRT20
keratin 20 [Source:HGN...
KRT38
8687
KRT38
keratin 38 [Source:HGN...
KRT4
3851
KRT4
keratin 4 [Source:HGNC...
LECT2
3950
LECT2
leukocyte cell derived...
LGALS7
3963
LGALS7
galectin 7 [Source:HGN...
LGALS9
3965
LGALS9
galectin 9 [Source:HGN...
LILRP2
79166
LILRP2
leukocyte immunoglobul...
LOC283079
100507605
LINC00837
long intergenic non-pr...
LOC283345
283345
RPL13P5
ribosomal protein L13 ...
LOC390688 /// LO
C441
LOC440895
440895
ENSG00000290731
novel transcript
LOC441259 /// LO
C641
LOC642671
LOC644974
644974
ALG1L2
ALG1 chitobiosyldiphos...
LOC650620
LOC653423
653423
SPAG11A
sperm associated antig...
LRAP
64167
ERAP2
endoplasmic reticulum ...
LSP1 /// LOC6493
77
LY6D
8581
LY6D
lymphocyte antigen 6 f...
MAML3
55534
MAML3
mastermind like transc...
MAP2K6
5608
MAP2K6
mitogen-activated prot...
MAP3K1
4214
MAP3K1
mitogen-activated prot...
MAST3
23031
MAST3
microtubule associated...
MEGF8
1954
MEGF8
multiple EGF like doma...
METTL7A
25840
TMT1A
thiol methyltransferas...
MMP27
64066
MMP27
matrix metallopeptidas...
MMP28
79148
MMP28
matrix metallopeptidas...
MRPL41
64975
MRPL41
mitochondrial ribosoma...
MST1 /// MSTP9
MTHFR
4524
MTHFR
methylenetetrahydrofol...
MXD3
83463
MXD3
MAX dimerization prote...
MXRA8
54587
MXRA8
matrix remodeling asso...
MYH7
4625
MYH7
myosin heavy chain 7 [...
MYL9
10398
MYL9
myosin light chain 9 [...
MYOM1
8736
MYOM1
myomesin 1 [Source:HGN...
MYOM2
9172
MYOM2
myomesin 2 [Source:HGN...
NAALADL1
10004
NAALADL1
N-acetylated alpha-lin...
NCR3
259197
NCR3
natural cytotoxicity t...
NEIL1
79661
NEIL1
nei like DNA glycosyla...
NEUROD1
4760
NEUROD1
neuronal differentiati...
NINJ1
4814
NINJ1
ninjurin 1 [Source:HGN...
NLGN4Y
22829
NLGN4Y
neuroligin 4 Y-linked ...
NOS1
4842
NOS1
nitric oxide synthase ...
NOX5
79400
NOX5
NADPH oxidase 5 [Sourc...
NSUN6
221078
NSUN6
NOP2/Sun RNA methyltra...
NTF3
4908
NTF3
neurotrophin 3 [Source...
OLFML2A
169611
OLFML2A
olfactomedin like 2A [...
OPN1MW /// OPN1L
W //
P2RX1
5023
P2RX1
purinergic receptor P2...
PAQR6
79957
PAQR6
progestin and adipoQ r...
PARP3
10039
PARP3
poly(ADP-ribose) polym...
PAX2
5076
PAX2
paired box 2 [Source:H...
PBX1
5087
PBX1
PBX homeobox 1 [Source...
PCDHB1
29930
PCDHB1
protocadherin beta 1 [...
PCSK2
5126
PCSK2
proprotein convertase ...
PDE3A
5139
PDE3A
phosphodiesterase 3A [...
PDE6B
5158
PDE6B
phosphodiesterase 6B [...
PIK3C2B
5287
PIK3C2B
phosphatidylinositol-4...
PLAC8
51316
PLAC8
placenta associated 8 ...
PLXND1
23129
PLXND1
plexin D1 [Source:HGNC...
POU4F2
5458
POU4F2
POU class 4 homeobox 2...
PPFIA2
8499
PPFIA2
PTPRF interacting prot...
PPFIA3
8541
PPFIA3
PTPRF interacting prot...
PPYR1
5540
NPY4R
neuropeptide Y recepto...
PRDM12
59335
PRDM12
PR/SET domain 12 [Sour...
PROC
5624
PROC
protein C, inactivator...
PRODH2
58510
PRODH2
proline dehydrogenase ...
PROM1
8842
PROM1
prominin 1 [Source:HGN...
PSORS1C1
170679
PSORS1C1
psoriasis susceptibili...
PTENP1
11191
PTENP1
phosphatase and tensin...
PTGFR
5737
PTGFR
prostaglandin F recept...
PTPRJ
5795
PTPRJ
protein tyrosine phosp...
PTPRU
10076
PTPRU
protein tyrosine phosp...
PVALB
5816
PVALB
parvalbumin [Source:HG...
PVRL1
5818
NECTIN1
nectin cell adhesion m...
PYHIN1
149628
PYHIN1
pyrin and HIN domain f...
RAG1
5896
RAG1
recombination activati...
RAMP3
10268
RAMP3
receptor activity modi...
RARRES2
5919
RARRES2
retinoic acid receptor...
RARRES3
5920
PLAAT4
phospholipase A and ac...
RBM17
84991
RBM17
RNA binding motif prot...
RHOQ /// LOC2849
88
RIMS1
22999
RIMS1
regulating synaptic me...
RP1-153G14.3
RP4-724E16.2
RPIB9
154661
RUNDC3B
RUN domain containing ...
RTP4
64108
RTP4
receptor transporter p...
RYR1
6261
RYR1
ryanodine receptor 1 [...
S100A12
6283
S100A12
S100 calcium binding p...
S100A7
6278
S100A7
S100 calcium binding p...
SCARF1
8578
SCARF1
scavenger receptor cla...
SCGB1A1
7356
SCGB1A1
secretoglobin family 1...
SCN10A
6336
SCN10A
sodium voltage-gated c...
SCN7A
6332
SCN7A
sodium voltage-gated c...
SDS
10993
SDS
serine dehydratase [So...
SELE
6401
SELE
selectin E [Source:HGN...
SELENBP1
8991
SELENBP1
selenium binding prote...
SERPINA10
51156
SERPINA10
serpin family A member...
SERPINB13
5275
SERPINB13
serpin family B member...
SERPINB3
6317
SERPINB3
serpin family B member...
SERPING1
710
SERPING1
serpin family G member...
SH3GL3
6457
SH3GL3
SH3 domain containing ...
SIDT1
54847
SIDT1
SID1 transmembrane fam...
SLC12A3
6559
SLC12A3
solute carrier family ...
SLC25A23
79085
SLC25A23
solute carrier family ...
SLC30A3
7781
SLC30A3
solute carrier family ...
SLC3A1
6519
SLC3A1
solute carrier family ...
SLC6A3
6531
SLC6A3
solute carrier family ...
SLC6A9
6536
SLC6A9
solute carrier family ...
SNN
8303
SNN
stannin [Source:HGNC S...
SOX11
6664
SOX11
SRY-box transcription ...
SPTBN2
6712
SPTBN2
spectrin beta, non-ery...
TAS2R4
50832
TAS2R4
taste 2 receptor membe...
TBKBP1
9755
TBKBP1
TBK1 binding protein 1...
TBR1
10716
TBR1
T-box brain transcript...
TEX15
56154
TEX15
testis expressed 15, m...
TGM1
7051
TGM1
transglutaminase 1 [So...
THAP9
79725
THAP9
THAP domain containing...
THBS3
7059
THBS3
thrombospondin 3 [Sour...
TM4SF4
7104
TM4SF4
transmembrane 4 L six ...
TNFRSF25 /// PLE
KHG5
TNFSF10
8743
TNFSF10
TNF superfamily member...
TNNI3
7137
TNNI3
troponin I3, cardiac t...
TRIM48
79097
TRIM48
tripartite motif conta...
TRIM58
25893
TRIM58
tripartite motif conta...
TRIM9
114088
TRIM9
tripartite motif conta...
TRPM2
7226
TRPM2
transient receptor pot...
TSHB
7252
TSHB
thyroid stimulating ho...
TTLL1
25809
TTLL1
TTL family tubulin pol...
TYRP1
7306
TYRP1
tyrosinase related pro...
UGT2A3
79799
UGT2A3
UDP glucuronosyltransf...
UPK3B
105375355
UPK3B
uroplakin 3B [Source:H...
VAV3
10451
VAV3
vav guanine nucleotide...
VAX2
25806
VAX2
ventral anterior homeo...
VCY /// VCX ///
VCX2
YBX2
51087
YBX2
Y-box binding protein ...
YPEL1
29799
YPEL1
yippee like 1 [Source:...
ZNF343
79175
ZNF343
zinc finger protein 34...
ZNF702
79986
ZNF702P
zinc finger protein 70...
ZNF750
79755
ZNF750
zinc finger protein 75...
ZSCAN2
54993
ZSCAN2
zinc finger and SCAN d...
Version history
See
MSigDB license terms here
. Please note that certain gene sets have special access terms.