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Human Gene Set: KRAS.LUNG.BREAST_UP.V1_DN
Standard name
KRAS.LUNG.BREAST_UP.V1_DN
Systematic name
M2898
Brief description
Genes down-regulated in epithelial breast cancer cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845 gene].
Full description or abstract
Collection
C6: Oncogenic Signature
Source publication
Exact source
AALE-KRAS vs AALE-Vector: top 300 genes (diff. of means). Similar to GSE17643: Broad KRAS internal signatures generated by J. Boehm.
Related gene sets
External links
Filtered by similarity
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Source species
Homo sapiens
Contributed by
Pablo Tamayo (Broad Institute)
Source platform or
identifier namespace
HUMAN_GENE_SYMBOL
Dataset references
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grp
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TSV metadata
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H: Hallmark
C1: Positional
C2: Curated
CGP: Chemical and Genetic Perturbations
CP: Canonical Pathways
CP:BIOCARTA: BioCarta Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
CP:PID: PID Pathways
CP:REACTOME: Reactome Pathways
CP:WIKIPATHWAYS: WikiPathways
CP:KEGG_LEGACY: KEGG Legacy Pathways
C3: Regulatory Target
MIR: microRNA Targets
MIR:MIRDB: miRDB
MIR:MIR_LEGACY: MIR_Legacy
TFT: Transcription Factor Targets
TFT:GTRD: GTRD
TFT:TFT_LEGACY: TFT_Legacy
C4: Computational
3CA: Curated Cancer Cell Atlas gene sets
CGN: Cancer Gene Neighborhoods
CM: Cancer Modules
C5: Ontology
GO: Gene Ontology
GO:BP: GO Biological Process
GO:CC: GO Cellular Component
GO:MF: GO Molecular Function
HPO: Human Phenotype Ontology
C6: Oncogenic Signature
C7: Immunologic Signature
IMMUNESIGDB: ImmuneSigDB
VAX: HIPC Vaccine Response
C8: Cell Type Signature
Compendia expression profiles
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NG-CHM interactive heatmaps
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query
Further investigate
these 142 genes
Gene families
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Categorize
these 142 genes by gene family
Show members
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150 source identifiers mapped to 142 genes)
Source
Id
NCBI (Entrez)
Gene Id
Gene
Symbol
Gene
Description
ADAMTS20
80070
ADAMTS20
ADAM metallopeptidase ...
ADD2
119
ADD2
adducin 2 [Source:HGNC...
AKAP6
9472
AKAP6
A-kinase anchoring pro...
AKR1B10
57016
AKR1B10
aldo-keto reductase fa...
ALDH5A1
7915
ALDH5A1
aldehyde dehydrogenase...
ALOX12B
242
ALOX12B
arachidonate 12-lipoxy...
AMBN
258
AMBN
ameloblastin [Source:H...
ANKRD1
27063
ANKRD1
ankyrin repeat domain ...
APOB
338
APOB
apolipoprotein B [Sour...
ART1
417
ART1
ADP-ribosyltransferase...
ATHL1
80162
PGGHG
protein-glucosylgalact...
ATP6V1B1
525
ATP6V1B1
ATPase H+ transporting...
BDKRB1
623
BDKRB1
bradykinin receptor B1...
C1R /// LOC64367
6
C20orf39
79953
SYNDIG1
synapse differentiatio...
C6orf10
10665
TSBP1
testis expressed basic...
CACNA1I
8911
CACNA1I
calcium voltage-gated ...
CALCB
797
CALCB
calcitonin related pol...
CALML3
810
CALML3
calmodulin like 3 [Sou...
CALML5
51806
CALML5
calmodulin like 5 [Sou...
CCDC121
79635
CCDC121
coiled-coil domain con...
CCDC132
55610
VPS50
VPS50 subunit of EARP/...
CD248
57124
CD248
CD248 molecule [Source...
CD36
948
CD36
CD36 molecule (CD36 bl...
CD6
923
CD6
CD6 molecule [Source:H...
CDH12
1010
CDH12
cadherin 12 [Source:HG...
CDH16
1014
CDH16
cadherin 16 [Source:HG...
CLCA2
9635
CLCA2
chloride channel acces...
CLDN8
9073
CLDN8
claudin 8 [Source:HGNC...
COBL
23242
COBL
cordon-bleu WH2 repeat...
COL2A1
1280
COL2A1
collagen type II alpha...
COL5A2
1290
COL5A2
collagen type V alpha ...
CRABP2
1382
CRABP2
cellular retinoic acid...
CXCL14
9547
CXCL14
C-X-C motif chemokine ...
CXCR7
57007
ACKR3
atypical chemokine rec...
CYP21A2
1589
CYP21A2
cytochrome P450 family...
DEFB1
1672
DEFB1
defensin beta 1 [Sourc...
DPT
1805
DPT
dermatopontin [Source:...
DTNB
1838
DTNB
dystrobrevin beta [Sou...
DTX2
113878
DTX2
deltex E3 ubiquitin li...
EMR1
2015
ADGRE1
adhesion G protein-cou...
EPB41L4A
64097
EPB41L4A
erythrocyte membrane p...
EPHX2
2053
EPHX2
epoxide hydrolase 2 [S...
FGFR3
2261
FGFR3
fibroblast growth fact...
FLJ10159
55084
SOBP
sine oculis binding pr...
FLJ10916
55258
THNSL2
threonine synthase lik...
FLJ22662
79887
PLBD1
phospholipase B domain...
FLT1
2321
FLT1
fms related receptor t...
FMO6
388714
FMO6P
flavin containing dime...
FRAS1
80144
FRAS1
Fraser extracellular m...
GABRA4
2557
GABRA4
gamma-aminobutyric aci...
GADD45G
10912
GADD45G
growth arrest and DNA ...
GAMT
2593
GAMT
guanidinoacetate N-met...
GDNF
2668
GDNF
glial cell derived neu...
GLS2
27165
GLS2
glutaminase 2 [Source:...
GLYAT
10249
GLYAT
glycine-N-acyltransfer...
GOLGA /// GOLGA6
///
GPR77
27202
C5AR2
complement C5a recepto...
HCN2
610
HCN2
hyperpolarization acti...
HHLA1
10086
HHLA1
HHLA1 neighbor of OC90...
HIST1H3A
8350
H3C1
H3 clustered histone 1...
HRK
8739
HRK
harakiri, BCL2 interac...
HTR1B
3351
HTR1B
5-hydroxytryptamine re...
HTR1E
3354
HTR1E
5-hydroxytryptamine re...
IFI44L
10964
IFI44L
interferon induced pro...
IFNA16
3449
IFNA16
interferon alpha 16 [S...
IGF2AS
51214
IGF2-AS
IGF2 antisense RNA [So...
IGFBP2
3485
IGFBP2
insulin like growth fa...
IL5RA
3568
IL5RA
interleukin 5 receptor...
INPP5D
3635
INPP5D
inositol polyphosphate...
IVL
3713
IVL
involucrin [Source:HGN...
KCNMB1
3779
KCNMB1
potassium calcium-acti...
KIAA1305
57523
NYNRIN
NYN domain and retrovi...
KIAA1660
KIF25
3834
KIF25
kinesin family member ...
KRT13
3860
KRT13
keratin 13 [Source:HGN...
KRT16
3868
KRT16
keratin 16 [Source:HGN...
KRT38
8687
KRT38
keratin 38 [Source:HGN...
KRT4
3851
KRT4
keratin 4 [Source:HGNC...
LGALS7
3963
LGALS7
galectin 7 [Source:HGN...
LGALS9
3965
LGALS9
galectin 9 [Source:HGN...
LOC283345
283345
RPL13P5
ribosomal protein L13 ...
LOC440895
440895
ENSG00000290731
novel transcript
LOC642671
LOC650620
LOC653423
653423
SPAG11A
sperm associated antig...
LRAP
64167
ERAP2
endoplasmic reticulum ...
LSP1 /// LOC6493
77
LY6D
8581
LY6D
lymphocyte antigen 6 f...
MAP2K6
5608
MAP2K6
mitogen-activated prot...
MAST3
23031
MAST3
microtubule associated...
MEGF8
1954
MEGF8
multiple EGF like doma...
METTL7A
25840
TMT1A
thiol methyltransferas...
MMP28
79148
MMP28
matrix metallopeptidas...
MTHFR
4524
MTHFR
methylenetetrahydrofol...
MXD3
83463
MXD3
MAX dimerization prote...
MXRA8
54587
MXRA8
matrix remodeling asso...
MYL9
10398
MYL9
myosin light chain 9 [...
NCR3
259197
NCR3
natural cytotoxicity t...
NOS1
4842
NOS1
nitric oxide synthase ...
NOX5
79400
NOX5
NADPH oxidase 5 [Sourc...
NSUN6
221078
NSUN6
NOP2/Sun RNA methyltra...
NTF3
4908
NTF3
neurotrophin 3 [Source...
OLFML2A
169611
OLFML2A
olfactomedin like 2A [...
OPN1MW /// OPN1L
W //
P2RX1
5023
P2RX1
purinergic receptor P2...
PAQR6
79957
PAQR6
progestin and adipoQ r...
PARP3
10039
PARP3
poly(ADP-ribose) polym...
PBX1
5087
PBX1
PBX homeobox 1 [Source...
PCDHB1
29930
PCDHB1
protocadherin beta 1 [...
PDE3A
5139
PDE3A
phosphodiesterase 3A [...
PDE6B
5158
PDE6B
phosphodiesterase 6B [...
PIK3C2B
5287
PIK3C2B
phosphatidylinositol-4...
PROC
5624
PROC
protein C, inactivator...
PTPRU
10076
PTPRU
protein tyrosine phosp...
PVALB
5816
PVALB
parvalbumin [Source:HG...
RAG1
5896
RAG1
recombination activati...
RAMP3
10268
RAMP3
receptor activity modi...
RARRES2
5919
RARRES2
retinoic acid receptor...
RBM17
84991
RBM17
RNA binding motif prot...
RPIB9
154661
RUNDC3B
RUN domain containing ...
RTP4
64108
RTP4
receptor transporter p...
RYR1
6261
RYR1
ryanodine receptor 1 [...
S100A7
6278
S100A7
S100 calcium binding p...
SCARF1
8578
SCARF1
scavenger receptor cla...
SCN7A
6332
SCN7A
sodium voltage-gated c...
SERPINA10
51156
SERPINA10
serpin family A member...
SERPINB13
5275
SERPINB13
serpin family B member...
SIDT1
54847
SIDT1
SID1 transmembrane fam...
SLC12A3
6559
SLC12A3
solute carrier family ...
SLC3A1
6519
SLC3A1
solute carrier family ...
SLC6A9
6536
SLC6A9
solute carrier family ...
SOX11
6664
SOX11
SRY-box transcription ...
SPTBN2
6712
SPTBN2
spectrin beta, non-ery...
TAS2R4
50832
TAS2R4
taste 2 receptor membe...
TBR1
10716
TBR1
T-box brain transcript...
TGM1
7051
TGM1
transglutaminase 1 [So...
TM4SF4
7104
TM4SF4
transmembrane 4 L six ...
TNFSF10
8743
TNFSF10
TNF superfamily member...
TNNI3
7137
TNNI3
troponin I3, cardiac t...
TRIM48
79097
TRIM48
tripartite motif conta...
TRIM9
114088
TRIM9
tripartite motif conta...
TRPM2
7226
TRPM2
transient receptor pot...
TSHB
7252
TSHB
thyroid stimulating ho...
TTLL1
25809
TTLL1
TTL family tubulin pol...
UPK3B
105375355
UPK3B
uroplakin 3B [Source:H...
VAV3
10451
VAV3
vav guanine nucleotide...
VAX2
25806
VAX2
ventral anterior homeo...
VCY /// VCX ///
VCX2
YPEL1
29799
YPEL1
yippee like 1 [Source:...
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