Human Gene Set: LIN_APC_TARGETS


Standard name LIN_APC_TARGETS
Systematic name M17434
Brief description Genes up-regulated by forced expression of APC [GeneID=324] in the APC-deficient SW480 cell line (colon cancer).
Full description or abstract To elucidate the molecular mechanism of colorectal carcinogenesis, we have been attempting to isolate genes involved in the beta-catenin/T-cell factor pathway. In the experiments reported here, analysis by cDNA microarray indicated that AF17, a fusion partner of the MLL gene in acute leukemias with t(11;17)(q23;q21), was transactivated according to accumulation of beta-catenin. Expression of AF17 was significantly enhanced in 8 of the 12 colorectal cancer tissues examined. Introduction of a plasmid designed to express AF17 stimulated growth of NIH3T3 cells, and fluorescence-activated cell sorter analysis indicated that the AF17 regulation of cell-cycle progression was occurring mainly at the G(2)-M transition. Our results suggest that the AF17 gene product is likely to be involved in the beta-catenin-T-cell factor/lymphoid enhancer factor signaling pathway and to function as a growth-promoting, oncogenic protein. These findings should aid development of new strategies for diagnosis, treatment, and prevention of colon cancers and acute leukemias by clarifying the pathogenesis of these conditions.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 11522623   Authors: Lin YM,Ono K,Satoh S,Ishiguro H,Fujita M,Miwa N,Tanaka T,Tsunoda T,Yang KC,Nakamura Y,Furukawa Y
Exact source Table 1
Related gene sets (show 23 gene sets from the same authors)
External links  
Filtered by similarity ?
Organism Homo sapiens
Contributed by Yujin Hoshida (Broad Institute)
Source platform HUMAN_SEQ_ACCESSION
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 71 genes
Gene families ? Categorize these 71 genes by gene family
Show members (show 84 members mapped to 71 genes)
Version history 3.0: Renamed from LIN_WNT_UP

See MSigDB license terms here. Please note that certain gene sets have special access terms.