Human Gene Set: LI_PBMC_MENACTRA_AGE_18_45YO_CORRELATED_WITH_ANTI_DT_ANTIBODY_3DY_NEGATIVE


Standard name LI_PBMC_MENACTRA_AGE_18_45YO_CORRELATED_WITH_ANTI_DT_ANTIBODY_3DY_NEGATIVE
Systematic name M40959
Brief description Genes negatively correlated with antibody response in peripheral blood mononuclear cell in adults (18-45) (anti-DT antibody-correlation profile) after exposure to Menactra , time point 3D
Full description or abstract Many vaccines induce protective immunity via antibodies. Systems biology approaches have been used to determine signatures that can be used to predict vaccine-induced immunity in humans, but whether there is a 'universal signature' that can be used to predict antibody responses to any vaccine is unknown. Here we did systems analyses of immune responses to the polysaccharide and conjugate vaccines against meningococcus in healthy adults, in the broader context of published studies of vaccines against yellow fever virus and influenza virus. To achieve this, we did a large-scale network integration of publicly available human blood transcriptomes and systems-scale databases in specific biological contexts and deduced a set of transcription modules in blood. Those modules revealed distinct transcriptional signatures of antibody responses to different classes of vaccines, which provided key insights into primary viral, protein recall and anti-polysaccharide responses. Our results elucidate the early transcriptional programs that orchestrate vaccine immunity in humans and demonstrate the power of integrative network modeling.
Collection C7: Immunologic Signature
      VAX: HIPC Vaccine Response
Source publication Pubmed 24336226   Authors: Li S,Rouphael N,Duraisingham S,Romero-Steiner S,Presnell S,Davis C,Schmidt DS,Johnson SE,Milton A,Rajam G,Kasturi S,Carlone GM,Quinn C,Chaussabel D,Palucka AK,Mulligan MJ,Ahmed R,Stephens DS,Nakaya HI,Pulendran B
Exact source Supplementary Fig 13
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External links https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946932/bin/NIHMS540680-supplement-13.jpg
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Source species Homo sapiens
Contributed by HIPC SIGNATURES (NIAID/HIPC SIGNATURES)
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identifier namespace		 HUMAN_GENE_SYMBOL
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