Human Gene Set: LI_PBMC_ZOSTAVAX_AGE_25_40_AND_60_79YO_3DY_UP

Standard name LI_PBMC_ZOSTAVAX_AGE_25_40_AND_60_79YO_3DY_UP
Systematic name M41084
Brief description Genes up-regulated in peripheral blood mononuclear cell 3d vs 0d in adults (25-40/60-79) after exposure to Zostavax , time point 3D
Full description or abstract Herpes zoster (shingles) causes significant morbidity in immune compromised hosts and older adults. Whereas a vaccine is available for prevention of shingles, its efficacy declines with age. To help to understand the mechanisms driving vaccinal responses, we constructed a multiscale, multifactorial response network (MMRN) of immunity in healthy young and older adults immunized with the live attenuated shingles vaccine Zostavax. Vaccination induces robust antigen-specific antibody, plasmablasts, and CD4+ T cells yet limited CD8+ T cell and antiviral responses. The MMRN reveals striking associations between orthogonal datasets, such as transcriptomic and metabolomics signatures, cell populations, and cytokine levels, and identifies immune and metabolic correlates of vaccine immunity. Networks associated with inositol phosphate, glycerophospholipids, and sterol metabolism are tightly coupled with immunity. Critically, the sterol regulatory binding protein 1 and its targets are key integrators of antibody and T follicular cell responses. Our approach is broadly applicable to study human immunity and can help to identify predictors of efficacy as well as mechanisms controlling immunity to vaccination.
Collection C7: Immunologic Signature
      VAX: HIPC Vaccine Response
Source publication Pubmed 28502771   Authors: Li S,Sullivan NL,Rouphael N,Yu T,Banton S,Maddur MS,McCausland M,Chiu C,Canniff J,Dubey S,Liu K,Tran V,Hagan T,Duraisingham S,Wieland A,Mehta AK,Whitaker JA,Subramaniam S,Jones DP,Sette A,Vora K,Weinberg A,Mulligan MJ,Nakaya HI,Levin M,Ahmed R,Pulendran B
Exact source Suppl Fig 2A
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