Human Gene Set: LY_AGING_OLD_UP


Standard name LY_AGING_OLD_UP
Systematic name M8910
Brief description Genes up-regulated in fibroblasts from old individuals, compared to those from young donors.
Full description or abstract Messenger RNA levels were measured in actively dividing fibroblasts isolated from young, middle-age, and old-age humans and humans with progeria, a rare genetic disorder characterized by accelerated aging. Genes whose expression is associated with age-related phenotypes and diseases were identified. The data also suggest that an underlying mechanism of the aging process involves increasing errors in the mitotic machinery of dividing cells in the postreproductive stage of life. We propose that this dysfunction leads to chromosomal pathologies that result in misregulation of genes involved in the aging process.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 10741968   Authors: Ly DH,Lockhart DJ,Lerner RA,Schultz PG
Exact source Table 1, 2: Old Age: FoldD > 0
Related gene sets (show 4 additional gene sets from the source publication)

(show 16 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
Source platform or
identifier namespace		 AFFY_HuGene
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 7 genes
Gene families ? Categorize these 7 genes by gene family
Show members (show 7 source identifiers mapped to 7 genes)
Version history  

A big thank you to everyone who responded to our request for emails of support for our grant application resubmission.
Reading them made us feel so appreciated and valued by all of you.

We hope we can continue to bring you GSEA/MSigDB in the years to come.
-The GSEA/MSigDB Team


See MSigDB license terms here. Please note that certain gene sets have special access terms.