Standard name |
MARSHALL_VIRAL_INFECTION_RESPONSE_DN |
Systematic name |
M1882 |
Brief description |
Genes down-regulated in the influenza-specific CD8+ [GeneID=925] T lymphocytes from bronchoalveolar lavage (BAL) compared to those from spleen. |
Full description or abstract |
The restriction of influenza A virus replication to mouse respiratory epithelium means that this host response is anatomically compartmentalized, on the one hand, to sites of T cell stimulation and proliferation in the secondary lymphoid tissue and, on the other hand, to the site of effector T cell function and pathology in the pneumonic lung. Thus, it is hardly surprising that virus-specific CD8(+) T cells recovered by bronchoalveolar lavage (BAL) from the infected respiratory tract seem more activated in terms of both cytolytic activity and cytokine production than those cells isolated from the spleen. The present analysis uses Affymetrix microarray technology to compare profiles of gene expression in these two lineage-related, yet anatomically separate, lymphocyte populations. Ninety differentially expressed genes were identified for influenza-specific CD8(+)D(b)NP(366)(+) T cells obtained directly ex vivo by BAL or spleen disruption, with nine genes being further analyzed by quantitative, real-time PCR at the population level. Integrin alphaE, for example, was shown by Affymetrix and real-time mRNA analyses and then by single-cell PCR and protein staining to be present at a much higher prevalence on the BAL CD8(+)D(b)NP(366)(+) set. The unpredicted finding, however, was that mRNA expression for 75% of the 90 genes was lower in T cells from the BAL than from the spleen. Apparently, the localization of virus-specific CD8(+) T cells to the site of virus-induced pathology is associated with a narrowing, or focusing, of gene expression that favors enhanced effector function in the damaged, high-antigen load environment of the pneumonic lung. |
Collection |
C2: Curated CGP: Chemical and Genetic Perturbations |
Source publication |
Pubmed 15831586 Authors: Marshall DR,Olivas E,Andreansky S,La Gruta NL,Neale GA,Gutierrez A,Wichlan DG,Wingo S,Cheng C,Doherty PC,Turner SJ |
Exact source |
Table 1 |
Related gene sets |
(show 1 additional gene sets from the source publication)
(show 41 gene sets from the same authors)
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External links |
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Source species |
Mus musculus |
Contributed by |
Arthur Liberzon (MSigDB Team) |
Source platform or identifier namespace |
MOUSE_SEQ_ACCESSION |
Dataset references |
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Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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these 29 genes
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29 genes by gene family
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Show members |
(show 32 source identifiers mapped to 29 genes)
Source Id |
NCBI (Entrez) Gene Id |
Gene Symbol |
Gene Description |
AA681998 |
1164 |
CKS2 |
CDC28 protein kinase regulatory subunit 2 ... |
AA764261 |
5292 |
PIM1 |
Pim-1 proto-oncogene, serine/threonine kin... |
AF053367 |
9124 |
PDLIM1 |
PDZ and LIM domain 1 [Source:HGNC Symbol;A... |
AF077347 |
8807 |
IL18RAP |
interleukin 18 receptor accessory protein ... |
AF097357 |
10219 |
KLRG1 |
killer cell lectin like receptor G1 [Sourc... |
AI019193 |
6932 |
TCF7 |
transcription factor 7 [Source:HGNC Symbol... |
AI591702 |
9493 |
KIF23 |
kinesin family member 23 [Source:HGNC Symb... |
AI642048 |
4792 |
NFKBIA |
NFKB inhibitor alpha [Source:HGNC Symbol;A... |
AI851658 |
51274 |
KLF3 |
KLF transcription factor 3 [Source:HGNC Sy... |
AJ006074 |
8698 |
S1PR4 |
sphingosine-1-phosphate receptor 4 [Source... |
AJ237939 |
6777 |
STAT5B |
signal transducer and activator of transcr... |
AW046181 |
6446 |
SGK1 |
serum/glucocorticoid regulated kinase 1 [S... |
D31956 |
924 |
CD7 |
CD7 molecule [Source:HGNC Symbol;Acc:HGNC:... |
D43963 |
7294 |
TXK |
TXK tyrosine kinase [Source:HGNC Symbol;Ac... |
D78382 |
10140 |
TOB1 |
transducer of ERBB2, 1 [Source:HGNC Symbol... |
D86232 |
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M12302 |
3002 |
GZMB |
granzyme B [Source:HGNC Symbol;Acc:HGNC:4709] |
M12848 |
4602 |
MYB |
MYB proto-oncogene, transcription factor [... |
M13226 |
3001 |
GZMA |
granzyme A [Source:HGNC Symbol;Acc:HGNC:4708] |
M68903 |
3695 |
ITGB7 |
integrin subunit beta 7 [Source:HGNC Symbo... |
M74516 |
2553 |
GABPB1 |
GA binding protein transcription factor su... |
M83380 |
5971 |
RELB |
RELB proto-oncogene, NF-kB subunit [Source... |
U19799 |
4793 |
NFKBIB |
NFKB inhibitor beta [Source:HGNC Symbol;Ac... |
U20238 |
22821 |
RASA3 |
RAS p21 protein activator 3 [Source:HGNC S... |
U25096 |
10365 |
KLF2 |
KLF transcription factor 2 [Source:HGNC Sy... |
U38252 |
1840 |
DTX1 |
deltex E3 ubiquitin ligase 1 [Source:HGNC ... |
U49513 |
6359 |
CCL15 |
C-C motif chemokine ligand 15 [Source:HGNC... |
U70494 |
3015 |
H2AZ1 |
H2A.Z variant histone 1 [Source:HGNC Symbo... |
U78171 |
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X57800 |
5111 |
PCNA |
proliferating cell nuclear antigen [Source... |
X75316 |
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X89749 |
7050 |
TGIF1 |
TGFB induced factor homeobox 1 [Source:HGN... |
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Version history |
3.1: First introduced
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