Human Gene Set: MARSHALL_VIRAL_INFECTION_RESPONSE_DN

For the Mouse gene set with the same name, see MARSHALL_VIRAL_INFECTION_RESPONSE_DN

Standard name MARSHALL_VIRAL_INFECTION_RESPONSE_DN
Systematic name M1882
Brief description Genes down-regulated in the influenza-specific CD8+ [GeneID=925] T lymphocytes from bronchoalveolar lavage (BAL) compared to those from spleen.
Full description or abstract The restriction of influenza A virus replication to mouse respiratory epithelium means that this host response is anatomically compartmentalized, on the one hand, to sites of T cell stimulation and proliferation in the secondary lymphoid tissue and, on the other hand, to the site of effector T cell function and pathology in the pneumonic lung. Thus, it is hardly surprising that virus-specific CD8(+) T cells recovered by bronchoalveolar lavage (BAL) from the infected respiratory tract seem more activated in terms of both cytolytic activity and cytokine production than those cells isolated from the spleen. The present analysis uses Affymetrix microarray technology to compare profiles of gene expression in these two lineage-related, yet anatomically separate, lymphocyte populations. Ninety differentially expressed genes were identified for influenza-specific CD8(+)D(b)NP(366)(+) T cells obtained directly ex vivo by BAL or spleen disruption, with nine genes being further analyzed by quantitative, real-time PCR at the population level. Integrin alphaE, for example, was shown by Affymetrix and real-time mRNA analyses and then by single-cell PCR and protein staining to be present at a much higher prevalence on the BAL CD8(+)D(b)NP(366)(+) set. The unpredicted finding, however, was that mRNA expression for 75% of the 90 genes was lower in T cells from the BAL than from the spleen. Apparently, the localization of virus-specific CD8(+) T cells to the site of virus-induced pathology is associated with a narrowing, or focusing, of gene expression that favors enhanced effector function in the damaged, high-antigen load environment of the pneumonic lung.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 15831586   Authors: Marshall DR,Olivas E,Andreansky S,La Gruta NL,Neale GA,Gutierrez A,Wichlan DG,Wingo S,Cheng C,Doherty PC,Turner SJ
Exact source Table 1
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Source species Mus musculus
Contributed by Arthur Liberzon (MSigDB Team)
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identifier namespace		 MOUSE_SEQ_ACCESSION
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