Standard name |
MARSHALL_VIRAL_INFECTION_RESPONSE_UP |
Systematic name |
M1881 |
Brief description |
Genes up-regulated in the influenza-specific CD8+ [GeneID=925] T lymphocytes from bronchoalveolar lavage (BAL) compared to those from spleen. |
Full description or abstract |
The restriction of influenza A virus replication to mouse respiratory epithelium means that this host response is anatomically compartmentalized, on the one hand, to sites of T cell stimulation and proliferation in the secondary lymphoid tissue and, on the other hand, to the site of effector T cell function and pathology in the pneumonic lung. Thus, it is hardly surprising that virus-specific CD8(+) T cells recovered by bronchoalveolar lavage (BAL) from the infected respiratory tract seem more activated in terms of both cytolytic activity and cytokine production than those cells isolated from the spleen. The present analysis uses Affymetrix microarray technology to compare profiles of gene expression in these two lineage-related, yet anatomically separate, lymphocyte populations. Ninety differentially expressed genes were identified for influenza-specific CD8(+)D(b)NP(366)(+) T cells obtained directly ex vivo by BAL or spleen disruption, with nine genes being further analyzed by quantitative, real-time PCR at the population level. Integrin alphaE, for example, was shown by Affymetrix and real-time mRNA analyses and then by single-cell PCR and protein staining to be present at a much higher prevalence on the BAL CD8(+)D(b)NP(366)(+) set. The unpredicted finding, however, was that mRNA expression for 75% of the 90 genes was lower in T cells from the BAL than from the spleen. Apparently, the localization of virus-specific CD8(+) T cells to the site of virus-induced pathology is associated with a narrowing, or focusing, of gene expression that favors enhanced effector function in the damaged, high-antigen load environment of the pneumonic lung. |
Collection |
C2: Curated CGP: Chemical and Genetic Perturbations |
Source publication |
Pubmed 15831586 Authors: Marshall DR,Olivas E,Andreansky S,La Gruta NL,Neale GA,Gutierrez A,Wichlan DG,Wingo S,Cheng C,Doherty PC,Turner SJ |
Exact source |
Table 1 |
Related gene sets |
(show 1 additional gene sets from the source publication)
(show 41 gene sets from the same authors)
|
External links |
|
Filtered by similarity ?
|
|
Source species |
Mus musculus |
Contributed by |
Arthur Liberzon (MSigDB Team) |
Source platform or identifier namespace |
MOUSE_SEQ_ACCESSION |
Dataset references |
|
Download gene set |
format: grp | gmt | xml | json | TSV metadata |
Compute overlaps ? |
(show collections to investigate for overlap with this gene set)
|
Compendia expression profiles ? |
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
|
Advanced query |
Further investigate
these 9 genes
|
Gene families ? |
Categorize these
9 genes by gene family
|
Show members |
(show 12 source identifiers mapped to 9 genes)
Source Id |
NCBI (Entrez) Gene Id |
Gene Symbol |
Gene Description |
AI835041 |
9406 |
ZRANB2 |
zinc finger RANBP2-type containing 2 [Sour... |
AI841654 |
9289 |
ADGRG1 |
adhesion G protein-coupled receptor G1 [So... |
AI853875 |
84937 |
ZNRF1 |
zinc and ring finger 1 [Source:HGNC Symbol... |
AJ223208 |
1520 |
CTSS |
cathepsin S [Source:HGNC Symbol;Acc:HGNC:2... |
AW122677 |
3669 |
ISG20 |
interferon stimulated exonuclease gene 20 ... |
M94584 |
27159 |
CHIA |
chitinase acidic [Source:HGNC Symbol;Acc:H... |
NM_029083 |
54541 |
DDIT4 |
DNA damage inducible transcript 4 [Source:... |
U12236 |
3682 |
ITGAE |
integrin subunit alpha E [Source:HGNC Symb... |
X04653 |
|
|
|
X15591 |
|
|
|
X15592 |
|
|
|
X17459 |
3516 |
RBPJ |
recombination signal binding protein for i... |
|
Version history |
3.1: First introduced
|
We need your help: Update on GSEA/MSigDB funding support
Last November we submitted a proposal to NCI's Information Technology for Cancer Research (ITCR) program for the continued
funding of GSEA and MSigDB. Unfortunately, our proposal was not funded in this round, but we were encouraged to resubmit
for the next one. This funding is critical for our continuing support and enhancement of the GSEA-MSigDB resource.
For our original submission many of you sent us emails of support, an important requirement for these grants. We
now ask for your help again. We would greatly appreciate a short email message from you describing how the resource
has been of value to your work and any concerns you may have about its continued availability.
Please send us your message of support to gsea-los@broadinstitute.org
on or before Monday June 5, 2023.
Thanks in advance for your help and support.
The GSEA/MSigDB Team.