Human Gene Set: MATSUDA_NATURAL_KILLER_DIFFERENTIATION

For the Mouse gene set with the same name, see MATSUDA_NATURAL_KILLER_DIFFERENTIATION

Standard name MATSUDA_NATURAL_KILLER_DIFFERENTIATION
Systematic name M18517
Brief description Genes changed between developmental stages of Valpha14i natural killer T lymphocyte cells (NKT).
Full description or abstract Valpha14i natural killer T (NKT)-cell function has been implicated in a number of disease conditions. The molecular events that drive Valpha14i NKT-cell development remain elusive. We recently showed that T-bet is required for the terminal maturation of these cells. Here we identify some of the genetic targets of T-bet during Valpha14i NKT-cell lineage development. Microarray gene-expression analyses on developing Valpha14i NKT cells were performed and provide a molecular framework to study these maturation events. In vitro ectopic expression of T-bet in immature Valpha14i NKT cells, which do not yet express T-bet, was sufficient to promote Valpha14i NKT-cell maturation, driving the expression of multiple genes, including those that participate in migration, survival, and effector functions. By regulating the expression of T-helper 1 (Th1)-associated cytokines, chemokines, chemokine receptors, and molecules involved in cytolysis, T-bet defines the unique lineage attributes of mature Valpha14i NKT cells and acts to link these attributes to a developmental process.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 16357323   Authors: Matsuda JL,Zhang Q,Ndonye R,Richardson SK,Howell AR,Gapin L
Exact source Table 1S
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Organism Mus musculus
Contributed by Kevin Vogelsang (MSigDB Team)
Source platform AFFY_Mouse430
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Version history 3.0: Renamed from MATSUDA_VALPHAINKT_DIFF

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