Human Gene Set: MA_RAT_AGING_DN

For the Mouse gene set with the same name, see MA_RAT_AGING_DN

Standard name MA_RAT_AGING_DN
Systematic name M46419
Brief description Genes down-regulated across multiple cell types from nine tissues during rat aging.
Full description or abstract Aging causes a functional decline in tissues throughout the body that may be delayed by caloric restriction (CR). However, the cellular profiles and signatures of aging, as well as those ameliorated by CR, remain unclear. Here, we built comprehensive single-cell and single-nucleus transcriptomic atlases across various rat tissues undergoing aging and CR. CR attenuated aging-related changes in cell type composition, gene expression, and core transcriptional regulatory networks. Immune cells were increased during aging, and CR favorably reversed the aging-disturbed immune ecosystem. Computational prediction revealed that the abnormal cell-cell communication patterns observed during aging, including the excessive proinflammatory ligand-receptor interplay, were reversed by CR. Our work provides multi-tissue single-cell transcriptional landscapes associated with aging and CR in a mammal, enhances our understanding of the robustness of CR as a geroprotective intervention, and uncovers how metabolic intervention can act upon the immune system to modify the process of aging.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 32109414   Authors: Ma S,Sun S,Geng L,Song M,Wang W,Ye Y,Ji Q,Zou Z,Wang S,He X,Li W,Esteban CR,Long X,Guo G,Chan P,Zhou Q,Belmonte JCI,Zhang W,Qu J,Liu GH
Exact source Table S2: LogFC<-0.5, genes downregulated at least in 5 cell types and the difference of the cell type number between downregulated and upregulated genes was greater than 5.
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Source species Rattus norvegicus
Contributed by Ma Shuai (Institute of Zoology, Chinese Academy of Sciences)
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Version history 2023.1.Hs: First Introduced.

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