Human Gene Set: MA_RAT_AGING_UP

For the Mouse gene set with the same name, see MA_RAT_AGING_UP

Standard name MA_RAT_AGING_UP
Systematic name M46418
Brief description Genes up-regulated across multiple cell types from nine tissues during rat aging.
Full description or abstract Aging causes a functional decline in tissues throughout the body that may be delayed by caloric restriction (CR). However, the cellular profiles and signatures of aging, as well as those ameliorated by CR, remain unclear. Here, we built comprehensive single-cell and single-nucleus transcriptomic atlases across various rat tissues undergoing aging and CR. CR attenuated aging-related changes in cell type composition, gene expression, and core transcriptional regulatory networks. Immune cells were increased during aging, and CR favorably reversed the aging-disturbed immune ecosystem. Computational prediction revealed that the abnormal cell-cell communication patterns observed during aging, including the excessive proinflammatory ligand-receptor interplay, were reversed by CR. Our work provides multi-tissue single-cell transcriptional landscapes associated with aging and CR in a mammal, enhances our understanding of the robustness of CR as a geroprotective intervention, and uncovers how metabolic intervention can act upon the immune system to modify the process of aging.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 32109414   Authors: Ma S,Sun S,Geng L,Song M,Wang W,Ye Y,Ji Q,Zou Z,Wang S,He X,Li W,Esteban CR,Long X,Guo G,Chan P,Zhou Q,Belmonte JCI,Zhang W,Qu J,Liu GH
Exact source Table S2: LogFC>0.5, genes upregulated at least in 5 cell types and the difference of the cell type number between upregulated and downregulated genes was greater than 5.
Related gene sets (show 1 additional gene sets from the source publication)

(show 631 gene sets from any of these authors)
External links https://ngdc.cncb.ac.cn/aging/index
Filtered by similarity ?
Source species Rattus norvegicus
Contributed by Ma Shuai (Institute of Zoology, Chinese Academy of Sciences)
Source platform or
identifier namespace		 RAT_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 107 genes
Gene families ? Categorize these 107 genes by gene family
Show members (show 124 source identifiers mapped to 107 genes)
Version history 2023.1.Hs: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.