Standard name |
MOOTHA_FFA_OXYDATION |
Systematic name |
M15531 |
Brief description |
Genes involved in free fatty acid oxidation; based on literature and sequence annotation resources and coverted to Affymetrix HG-U133A probe sets. |
Full description or abstract |
DNA microarrays can be used to identify gene expression changes characteristic of human disease. This is challenging, however, when relevant differences are subtle at the level of individual genes. We introduce an analytical strategy, Gene Set Enrichment Analysis, designed to detect modest but coordinate changes in the expression of groups of functionally related genes. Using this approach, we identify a set of genes involved in oxidative phosphorylation whose expression is coordinately decreased in human diabetic muscle. Expression of these genes is high at sites of insulin-mediated glucose disposal, activated by PGC-1alpha and correlated with total-body aerobic capacity. Our results associate this gene set with clinically important variation in human metabolism and illustrate the value of pathway relationships in the analysis of genomic profiling experiments. |
Collection |
C2: Curated CGP: Chemical and Genetic Perturbations |
Source publication |
Pubmed 12808457 Authors: Mootha VK,Lindgren CM,Eriksson KF,Subramanian A,Sihag S,Lehar J,Puigserver P,Carlsson E,Ridderstråle M,Laurila E,Houstis N,Daly MJ,Patterson N,Mesirov JP,Golub TR,Tamayo P,Spiegelman B,Lander ES,Hirschhorn JN,Altshuler D,Groop LC |
Exact source |
Suppl. file: all_pathways/FA_HG-U133A_probes |
Related gene sets |
(show 10 additional gene sets from the source publication)
(show 399 gene sets from the same authors)
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External links |
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Filtered by similarity ?
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Source species |
Homo sapiens |
Contributed by |
Vamsi Mootha (Broad Institute) |
Source platform or identifier namespace |
AFFY_HG_U133 |
Dataset references |
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Download gene set |
format: grp | gmt | xml | json | TSV metadata |
Compute overlaps ? |
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Compendia expression profiles ? |
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Advanced query |
Further investigate
these 24 genes
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Gene families ? |
Categorize these
24 genes by gene family
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Show members |
(show 34 source identifiers mapped to 24 genes)
Source Id |
NCBI (Entrez) Gene Id |
Gene Symbol |
Gene Description |
200710_at |
37 |
ACADVL |
acyl-CoA dehydrogenase very long c... |
201007_at |
3032 |
HADHB |
hydroxyacyl-CoA dehydrogenase trif... |
201035_s_at |
3033 |
HADH |
hydroxyacyl-CoA dehydrogenase [Sou... |
201036_s_at |
3033 |
HADH |
hydroxyacyl-CoA dehydrogenase [Sou... |
201135_at |
1892 |
ECHS1 |
enoyl-CoA hydratase, short chain 1... |
201963_at |
2180 |
ACSL1 |
acyl-CoA synthetase long chain fam... |
202003_s_at |
10449 |
ACAA2 |
acetyl-CoA acyltransferase 2 [Sour... |
202282_at |
3028 |
HSD17B10 |
hydroxysteroid 17-beta dehydrogena... |
202366_at |
35 |
ACADS |
acyl-CoA dehydrogenase short chain... |
202447_at |
1666 |
DECR1 |
2,4-dienoyl-CoA reductase 1 [Sourc... |
202502_at |
34 |
ACADM |
acyl-CoA dehydrogenase medium chai... |
202906_s_at |
4683 |
NBN |
nibrin [Source:HGNC Symbol;Acc:HGN... |
203634_s_at |
1374 |
CPT1A |
carnitine palmitoyltransferase 1A ... |
204263_s_at |
1376 |
CPT2 |
carnitine palmitoyltransferase 2 [... |
204264_at |
1376 |
CPT2 |
carnitine palmitoyltransferase 2 [... |
205355_at |
36 |
ACADSB |
acyl-CoA dehydrogenase short/branc... |
205412_at |
38 |
ACAT1 |
acetyl-CoA acetyltransferase 1 [So... |
205843_x_at |
1384 |
CRAT |
carnitine O-acetyltransferase [Sou... |
206069_s_at |
33 |
ACADL |
acyl-CoA dehydrogenase long chain ... |
207275_s_at |
2180 |
ACSL1 |
acyl-CoA synthetase long chain fam... |
208629_s_at |
3030 |
HADHA |
hydroxyacyl-CoA dehydrogenase trif... |
208631_s_at |
3030 |
HADHA |
hydroxyacyl-CoA dehydrogenase trif... |
209426_s_at |
23600 |
AMACR |
alpha-methylacyl-CoA racemase [Sou... |
209522_s_at |
1384 |
CRAT |
carnitine O-acetyltransferase [Sou... |
209759_s_at |
1632 |
ECI1 |
enoyl-CoA delta isomerase 1 [Sourc... |
210069_at |
1375 |
CPT1B |
carnitine palmitoyltransferase 1B ... |
210070_s_at |
1375 |
CPT1B |
carnitine palmitoyltransferase 1B ... |
210687_at |
1374 |
CPT1A |
carnitine palmitoyltransferase 1A ... |
210688_s_at |
1374 |
CPT1A |
carnitine palmitoyltransferase 1A ... |
211569_s_at |
3033 |
HADH |
hydroxyacyl-CoA dehydrogenase [Sou... |
217111_at |
128385370 |
FHP2 |
fumarate hydratase (FH) pseudogene |
217113_at |
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31837_at |
91289 |
LMF2 |
lipase maturation factor 2 [Source... |
40640_at |
29781 |
NCAPH2 |
non-SMC condensin II complex subun... |
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Version history |
3.0: First introduced
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A big thank you to everyone who responded to our request for emails of support for our grant application resubmission.
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