Standard name |
MOOTHA_GLYCOGEN_METABOLISM |
Systematic name |
M10376 |
Brief description |
Genes involved in glycogen metabolism; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets. |
Full description or abstract |
DNA microarrays can be used to identify gene expression changes characteristic of human disease. This is challenging, however, when relevant differences are subtle at the level of individual genes. We introduce an analytical strategy, Gene Set Enrichment Analysis, designed to detect modest but coordinate changes in the expression of groups of functionally related genes. Using this approach, we identify a set of genes involved in oxidative phosphorylation whose expression is coordinately decreased in human diabetic muscle. Expression of these genes is high at sites of insulin-mediated glucose disposal, activated by PGC-1alpha and correlated with total-body aerobic capacity. Our results associate this gene set with clinically important variation in human metabolism and illustrate the value of pathway relationships in the analysis of genomic profiling experiments. |
Collection |
C2: Curated CGP: Chemical and Genetic Perturbations |
Source publication |
Pubmed 12808457 Authors: Mootha VK,Lindgren CM,Eriksson KF,Subramanian A,Sihag S,Lehar J,Puigserver P,Carlsson E,Ridderstråle M,Laurila E,Houstis N,Daly MJ,Patterson N,Mesirov JP,Golub TR,Tamayo P,Spiegelman B,Lander ES,Hirschhorn JN,Altshuler D,Groop LC |
Exact source |
Suppl. file: all_pathways/GLYCOGEN_HG-U133A_probes |
Related gene sets |
(show 10 additional gene sets from the source publication)
(show 399 gene sets from the same authors)
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External links |
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Filtered by similarity ?
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Source species |
Homo sapiens |
Contributed by |
Vamsi Mootha (Broad Institute) |
Source platform or identifier namespace |
AFFY_HG_U133 |
Dataset references |
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Download gene set |
format: grp | gmt | xml | json | TSV metadata |
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Compendia expression profiles ? |
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Advanced query |
Further investigate
these 21 genes
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Gene families ? |
Categorize these
21 genes by gene family
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Show members |
(show 27 source identifiers mapped to 21 genes)
Source Id |
NCBI (Entrez) Gene Id |
Gene Symbol |
Gene Description |
200726_at |
5501 |
PPP1CC |
protein phosphatase 1 catalytic subunit... |
200846_s_at |
5499 |
PPP1CA |
protein phosphatase 1 catalytic subunit... |
201409_s_at |
5500 |
PPP1CB |
protein phosphatase 1 catalytic subunit... |
201554_x_at |
2992 |
GYG1 |
glycogenin 1 [Source:HGNC Symbol;Acc:HG... |
201673_s_at |
2997 |
GYS1 |
glycogen synthase 1 [Source:HGNC Symbol... |
202166_s_at |
5504 |
PPP1R2 |
protein phosphatase 1 regulatory inhibi... |
202812_at |
2548 |
GAA |
alpha glucosidase [Source:HGNC Symbol;A... |
202830_s_at |
2542 |
SLC37A4 |
solute carrier family 37 member 4 [Sour... |
202990_at |
5836 |
PYGL |
glycogen phosphorylase L [Source:HGNC S... |
203282_at |
2632 |
GBE1 |
1,4-alpha-glucan branching enzyme 1 [So... |
203566_s_at |
178 |
AGL |
amylo-alpha-1, 6-glucosidase, 4-alpha-g... |
204555_s_at |
5509 |
PPP1R3D |
protein phosphatase 1 regulatory subuni... |
205577_at |
5837 |
PYGM |
glycogen phosphorylase, muscle associat... |
206867_at |
2646 |
GCKR |
glucokinase regulator [Source:HGNC Symb... |
206895_at |
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206952_at |
2538 |
G6PC1 |
glucose-6-phosphatase catalytic subunit... |
209439_s_at |
5256 |
PHKA2 |
phosphorylase kinase regulatory subunit... |
209945_s_at |
2932 |
GSK3B |
glycogen synthase kinase 3 beta [Source... |
210963_s_at |
8908 |
GYG2 |
glycogenin 2 [Source:HGNC Symbol;Acc:HG... |
210964_s_at |
8908 |
GYG2 |
glycogenin 2 [Source:HGNC Symbol;Acc:HG... |
211169_s_at |
5506 |
PPP1R3A |
protein phosphatase 1 regulatory subuni... |
211275_s_at |
2992 |
GYG1 |
glycogenin 1 [Source:HGNC Symbol;Acc:HG... |
213478_at |
23254 |
KAZN |
kazrin, periplakin interacting protein ... |
214621_at |
2998 |
GYS2 |
glycogen synthase 2 [Source:HGNC Symbol... |
215138_s_at |
23254 |
KAZN |
kazrin, periplakin interacting protein ... |
215695_s_at |
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217289_s_at |
2542 |
SLC37A4 |
solute carrier family 37 member 4 [Sour... |
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Version history |
3.0: First introduced
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