Standard name |
MOOTHA_GLYCOLYSIS |
Systematic name |
M16111 |
Brief description |
Genes involved in glycolysis; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets. |
Full description or abstract |
DNA microarrays can be used to identify gene expression changes characteristic of human disease. This is challenging, however, when relevant differences are subtle at the level of individual genes. We introduce an analytical strategy, Gene Set Enrichment Analysis, designed to detect modest but coordinate changes in the expression of groups of functionally related genes. Using this approach, we identify a set of genes involved in oxidative phosphorylation whose expression is coordinately decreased in human diabetic muscle. Expression of these genes is high at sites of insulin-mediated glucose disposal, activated by PGC-1alpha and correlated with total-body aerobic capacity. Our results associate this gene set with clinically important variation in human metabolism and illustrate the value of pathway relationships in the analysis of genomic profiling experiments. |
Collection |
C2: Curated CGP: Chemical and Genetic Perturbations |
Source publication |
Pubmed 12808457 Authors: Mootha VK,Lindgren CM,Eriksson KF,Subramanian A,Sihag S,Lehar J,Puigserver P,Carlsson E,Ridderstråle M,Laurila E,Houstis N,Daly MJ,Patterson N,Mesirov JP,Golub TR,Tamayo P,Spiegelman B,Lander ES,Hirschhorn JN,Altshuler D,Groop LC |
Exact source |
Suppl. file: all_pathways/GLYCOL_HG-U133A_probes |
Related gene sets |
(show 10 additional gene sets from the source publication)
(show 399 gene sets from the same authors)
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External links |
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Filtered by similarity ?
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Source species |
Homo sapiens |
Contributed by |
Vamsi Mootha (Broad Institute) |
Source platform or identifier namespace |
AFFY_HG_U133 |
Dataset references |
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Download gene set |
format: grp | gmt | xml | json | TSV metadata |
Compute overlaps ? |
(show collections to investigate for overlap with this gene set)
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Compendia expression profiles ? |
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Advanced query |
Further investigate
these 21 genes
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Gene families ? |
Categorize these
21 genes by gene family
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Show members |
(show 31 source identifiers mapped to 21 genes)
Source Id |
NCBI (Entrez) Gene Id |
Gene Symbol |
Gene Description |
200697_at |
3098 |
HK1 |
hexokinase 1 [Source:HGNC Symbol;Acc:HGN... |
200737_at |
5230 |
PGK1 |
phosphoglycerate kinase 1 [Source:HGNC S... |
200738_s_at |
5230 |
PGK1 |
phosphoglycerate kinase 1 [Source:HGNC S... |
200822_x_at |
7167 |
TPI1 |
triosephosphate isomerase 1 [Source:HGNC... |
200966_x_at |
226 |
ALDOA |
aldolase, fructose-bisphosphate A [Sourc... |
201231_s_at |
2023 |
ENO1 |
enolase 1 [Source:HGNC Symbol;Acc:HGNC:3... |
201251_at |
5315 |
PKM |
pyruvate kinase M1/2 [Source:HGNC Symbol... |
201313_at |
2026 |
ENO2 |
enolase 2 [Source:HGNC Symbol;Acc:HGNC:3... |
201968_s_at |
5236 |
PGM1 |
phosphoglucomutase 1 [Source:HGNC Symbol... |
202022_at |
230 |
ALDOC |
aldolase, fructose-bisphosphate C [Sourc... |
203547_at |
920 |
CD4 |
CD4 molecule [Source:HGNC Symbol;Acc:HGN... |
204483_at |
2027 |
ENO3 |
enolase 3 [Source:HGNC Symbol;Acc:HGNC:3... |
204705_x_at |
229 |
ALDOB |
aldolase, fructose-bisphosphate B [Sourc... |
205736_at |
5224 |
PGAM2 |
phosphoglycerate mutase 2 [Source:HGNC S... |
206844_at |
8789 |
FBP2 |
fructose-bisphosphatase 2 [Source:HGNC S... |
207116_s_at |
26330 |
GAPDHS |
glyceraldehyde-3-phosphate dehydrogenase... |
207537_at |
5207 |
PFKFB1 |
6-phosphofructo-2-kinase/fructose-2,6-bi... |
207931_s_at |
5208 |
PFKFB2 |
6-phosphofructo-2-kinase/fructose-2,6-bi... |
208308_s_at |
2821 |
GPI |
glucose-6-phosphate isomerase [Source:HG... |
209696_at |
2203 |
FBP1 |
fructose-bisphosphatase 1 [Source:HGNC S... |
209992_at |
5208 |
PFKFB2 |
6-phosphofructo-2-kinase/fructose-2,6-bi... |
210050_at |
7167 |
TPI1 |
triosephosphate isomerase 1 [Source:HGNC... |
210848_at |
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210976_s_at |
5213 |
PFKM |
phosphofructokinase, muscle [Source:HGNC... |
211357_s_at |
229 |
ALDOB |
aldolase, fructose-bisphosphate B [Sourc... |
211725_s_at |
637 |
BID |
BH3 interacting domain death agonist [So... |
214687_x_at |
226 |
ALDOA |
aldolase, fructose-bisphosphate A [Sourc... |
216554_s_at |
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216600_x_at |
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217238_s_at |
229 |
ALDOB |
aldolase, fructose-bisphosphate B [Sourc... |
217294_s_at |
2023 |
ENO1 |
enolase 1 [Source:HGNC Symbol;Acc:HGNC:3... |
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Version history |
3.0: First introduced
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