Human Gene Set: MTOR_UP.N4.V1_DN


Standard name MTOR_UP.N4.V1_DN
Systematic name M2756
Brief description Genes down-regulated in CEM-C1 cells (T-CLL) in comparison of control vs rapamycin (sirolimus) [PubChem=6610346], an mTOR pathway inhibitor.
Full description or abstract CEM-C1 cells were treated with 10 nM rapamycin or DMSO and harvested for microarray analysis at 24 hours
Collection C6: Oncogenic Signature
Source publication Pubmed 17010674   Authors: Wei G,Twomey D,Lamb J,Schlis K,Agarwal J,Stam RW,Opferman JT,Sallan SE,den Boer ML,Pieters R,Golub TR,Armstrong SA
Exact source contol (DMSO) vs 24h of rapamycin treatment; bottom 200 genes (diff. of means)
Related gene sets (show 1 additional gene sets from the source publication)

(show 312 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
Source platform or
identifier namespace
HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 184 genes
Gene families ? Categorize these 184 genes by gene family
Show members (show 200 source identifiers mapped to 184 genes)
Version history  

A big thank you to everyone who responded to our request for emails of support for our grant application resubmission.
Reading them made us feel so appreciated and valued by all of you.

We hope we can continue to bring you GSEA/MSigDB in the years to come.
-The GSEA/MSigDB Team


See MSigDB license terms here. Please note that certain gene sets have special access terms.