Human Gene Set: NABA_MATRISOME_HGSOC_OMENTAL_METASTASIS


Standard name NABA_MATRISOME_HGSOC_OMENTAL_METASTASIS
Systematic name M47993
Brief description Matrisome proteins detected in significantly different abundance in omentum metastases from high grade serous ovarian cancer (HGSOC) compared to normal omentum.
Full description or abstract Patient samples were kindly donated by women with high-grade serous ovarian cancer (HGSOC). We optimized protocols to solubilize ECM proteins from normal or tumor tissues, digest the proteins into peptides, analyze ECM peptides by mass spectrometry, and interpret the mass spectrometric data. Using LC-MS/MS, we analyzed ECM-enriched samples of disease-free omentum from patients with non-metastatic ovarian cancer and HGSOC-derived omental metastasis samples. A second critical step of the approach was the identification and annotation of the ECM components, or matrisome, in large proteomic data sets. The curation of this signature utilized crude ECM extracts rather than urea-soluable extracts. This gene set lists the matrisome proteins detected in significantly differential abundance in omentum metastases from high grade serous ovarian cancer (HGSOC) compared to normal omentum.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 28675934   Authors: Naba A,Pearce OMT,Del Rosario A,Ma D,Ding H,Rajeeve V,Cutillas PR,Balkwill FR,Hynes RO
Exact source Supplementary Table S1D
Related gene sets (show 32 gene sets from the same authors)
External links https://doi.org/10.1021/acs.jproteome.7b00191
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Source species Homo sapiens
Contributed by Alexandra Naba (University of Illinois Chicago)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 2023.2.Hs: First Introduced.

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